Regulation of Protein Stability and Signaling in EIF3G-rich Tissues and Cells

Target Name: EIF3G

NCBI ID: G8666

EIF3G

Regulation of Protein Stability and Signaling in EIF3G-rich Tissues and Cells

EIF3G, also known as EIF3p42, is a protein that is expressed in various tissues and cells in the body. It is a key regulator of the heat shock response, which is a critical stress response that helps the cell to survive and adapt to different environments. EIF3G plays a crucial role in the regulation of protein stability, which is a critical factor in the regulation of cellular processes such as cell growth, apoptosis, and inflammation.

Recent studies have identified EIF3G as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. The heat shock response is a critical pathway that is involved in the regulation of protein stability, and EIF3G is a key regulator of this pathway. By targeting EIF3G, researchers hope to gain insights into the mechanisms of protein stability and how this regulation contributes to the survival and dysfunction of cells.

One of the key features of EIF3G is its ability to interact with various protein substrates, including histones, which are important regulators of gene expression. Histones are small proteins that play a structural role in the nucleus of the cell, and they are involved in the regulation of DNA replication, gene expression, and cell signaling. EIF3G has been shown to interact with histones and to regulate their stability, which suggests that it plays a critical role in the regulation of cellular processes that are dependent on protein stability.

In addition to its role in the regulation of protein stability, EIF3G is also involved in the regulation of cellular signaling pathways. It has been shown to be involved in a variety of signaling pathways, including the TOR signaling pathway, the PI3K/Akt signaling pathway, and the NF-kappa-B signaling pathway. These signaling pathways are involved in the regulation of cellular processes such as cell growth, apoptosis, and inflammation, and EIF3G is thought to play a critical role in the regulation of these processes.

EIF3G is also involved in the regulation of protein folding, which is the process by which proteins are formed from their amino acid sequence. Proteins must be correctlyfolded in order to have their correct function, and EIF3G is involved in the regulation of the folding of various proteins, including proteins involved in cell signaling, cell adhesion, and inflammation.

In conclusion, EIF3G is a protein that is involved in a variety of cellular processes that are dependent on protein stability and signaling. Its role in these processes makes it a potential drug target or biomarker for various diseases. Further research is needed to fully understand the mechanisms of EIF3G's role in cellular processes and its potential as a drug target or biomarker.

Protein Name: Eukaryotic Translation Initiation Factor 3 Subunit G

Functions: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA

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