EIF3I: A Protein Target for Drug Development (G8668)

Target Name: EIF3I

NCBI ID: G8668

EIF3I

EIF3I: A Protein Target for Drug Development

EIF3I (EIF3I variant 1) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a key regulator of the homeostasis of cells, and is involved in a wide range of physiological processes that are essential for life.

Recent studies have identified EIF3I as a potential drug target, due to its involvement in a number of diseases and disorders. In this article, we will discuss the biology and function of EIF3I, and the potential implications of targeting this protein.

EIF3I is a member of the EIF3I family, which includes a number of similar proteins that are involved in the regulation of cell survival and homeostasis. These proteins are characterized by the presence of a unique domain called the N-terminal hypervariable region (HVR), which is responsible for the diversity of their sequence and function.

The N-terminal HVR of EIF3I is a structural domain that is composed of multiple amino acids that are involved in the formation of a hydrogen-bonded network. This network is thought to play a role in the regulation of the stability of the protein, by allowing it to interact with various molecules in the cell.

One of the key functions of EIF3I is its role in the regulation of cell division. EIF3I is a critical regulator of the G1 phase of cell division, during which the cell prepares for cell division by producing a significant amount of cyclin D1. Cyclin D1 is a protein that is involved in the regulation of cell cycle progression, and it is produced by the enzyme cyclin D1-CDK4.

In addition to its role in cell division, EIF3I is also involved in the regulation of cell survival. It has been shown to play a role in the regulation of cell apoptosis, or programmed cell death. This is thought to happen through its involvement in the formation of a protein called Bcl-2, which is involved in the regulation of apoptosis.

EIF3I is also involved in the regulation of inflammation, and has been shown to play a role in the regulation of the immune response. It has been shown to interact with a protein called PDCD4, which is involved in the regulation of immune cell function.

In addition to its involvement in cell division, apoptosis, and inflammation, EIF3I is also involved in the regulation of a number of other physiological processes. For example, it is involved in the regulation of cell signaling, and has been shown to play a role in the regulation of cell-cell interactions.

Given its involvement in a wide range of physiological processes, EIF3I is a promising target for drug development. In the future, studies are likely to continue to uncover the full range of functions and interactions of EIF3I, and to develop new treatments based on these insights.

Overall, EIF3I is a protein that is involved in a wide range of physiological processes, and has the potential to be a valuable drug target. Further research is needed to fully understand its role in the regulation of cell function, and to develop new treatments based on these insights.

Protein Name: Eukaryotic Translation Initiation Factor 3 Subunit I

Functions: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773)

The "EIF3I Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about EIF3I comprehensively, including but not limited to:
•   general information;
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•   the target screening and validation;
•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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