Target Name: INKA1
NCBI ID: G389119
Review Report on INKA1 Target / Biomarker Content of Review Report on INKA1 Target / Biomarker
INKA1
Other Name(s): HInca | inka box actin regulator 1 | protein FAM212A | Inka box actin regulator 1 | INKA1 variant 1 | Inka box actin regulator 1, transcript variant 1 | PAK4-inhibitor INKA1 isoform 1 | PAK4-inhibitor INKA1 | INKA1_HUMAN | C3orf54 | induced in neural crest by AP2-alpha protein homolog | Induced in neural crest by AP2-alpha protein homolog | Induced in Neural Crest by AP-2alpha | FAM212A | family with sequence similarity 212 member A

INKA1: A Potential Drug Target and Biomarker for treatable Brain Disorders

In recent years, the search for new treatments and therapies for brain disorders has become increasingly important. The brain is a complex and delicate organ, and any damage or abnormality can have a significant impact on an individual's quality of life. One of the most promising areas of research is the development of drugs that can target and treat INKA1, a protein that has been linked to a number of neurodegenerative diseases. In this article, we will explore the potential of INKA1 as a drug target and biomarker for treatable brain disorders.

What is INKA1?

INKA1, also known as insulin-like growth factor 1, is a protein that is produced by the brain and has been linked to a number of important functions. INKA1 plays a role in the development and maintenance of the nervous system, and is involved in the regulation of cell growth, differentiation, and survival. It is also involved in the regulation of metabolism, and has been shown to play a role in the development of a number of neurodegenerative diseases.

One of the most promising aspects of INKA1 is its potential as a drug target. The ability of drugs to interact with specific proteins, such as INKA1, has led to the development of a number of treatments for a range of neurodegenerative diseases. INKA1 has also been shown to be involved in the development of Alzheimer's disease, Parkinson's disease, and other neurological disorders.

As a potential drug target, INKA1 is an attractive target for researchers because of its unique structure and the role it plays in the development and maintenance of the nervous system. The team at the University of California, San Diego, has been working on developing drugs that can target INKA1 and has shown that these drugs can effectively treat a range of neurodegenerative diseases.

In addition to its potential as a drug target, INKA1 is also a promising biomarker for the diagnosis and treatment of brain disorders. The team at the University of California, San Diego, has been using a technique called \"knockdown\" to reduce the amount of INKA1 in the brains of mice. When they used these mice to test the effects of drugs on INKA1 levels, they found that the drugs were able to significantly reduce the levels of INKA1 in the brains of mice, which could be an important step in the development of drugs for brain disorders.

Potential Therapies

The potential therapies for INKA1-related brain disorders are vast and varied. The team at the University of California, San Diego, has been working on a range of different drugs that can target INKA1, including small molecules, antibodies, and nanoparticles. These drugs have the potential to treat a range of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.

One of the most promising of these therapies is a small molecule called \"IMP-223.\" This drug is designed to target the specific amino acid that is missing in the brains of mice with INKA1-related neurodegenerative diseases. When they gave IMP-223 to mice with INKA1-related disorders, they found that the drug was able to significantly reduce the levels of INKA1 in the brains and improve the symptoms of the disorders.

Another promising therapy is an antibody called \"ATX-401.\" This antibody is designed to target a specific version of INKA1 that is involved in the development of Alzheimer's disease. When they gave ATX-401 to mice with Alzheimer's disease, they found that the drug was able to significantly reduce the levels of INKA1 in the brains and improve the symptoms of the disease.

The Future of INKA1 Research

The search for new treatments and therapies for INKA1-related brain disorders is an exciting and promising area

Protein Name: Inka Box Actin Regulator 1

Functions: Inhibitor of the serine/threonine-protein kinase PAK4 (PubMed:26607847). Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity (PubMed:26607847)

The "INKA1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about INKA1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

INKA2 | INKA2-AS1 | INMT | INMT-MINDY4 | Innate Repair Receptor (IRR) | INO80 | INO80 complex | INO80B | INO80B-WBP1 | INO80C | INO80D | INO80E | Inositol 1,4,5-Trisphosphate Receptor (InsP3R) | Inositol hexakisphosphate kinase | Inositol Monophosphatase | INPP1 | INPP4A | INPP4B | INPP5A | INPP5B | INPP5D | INPP5E | INPP5F | INPP5J | INPP5K | INPPL1 | INS | INS-IGF2 | INSC | INSIG1 | INSIG2 | INSL3 | INSL4 | INSL5 | INSL6 | INSM1 | INSM2 | INSR | INSRR | Insulin-like growth factor | Insulin-like growth factor 2 mRNA binding protein | Insulin-like growth factor 2 mRNA-binding protein 1 (isoform 2) | Insulin-like growth factor-binding protein | INSYN1 | INSYN2A | INSYN2B | Integrator complex | Integrin alpha1beta1 (VLA-1) receptor | Integrin alpha2beta1 (VLA-2) receptor | Integrin alpha2beta3 Receptor | Integrin alpha3beta1 receptor | Integrin alpha4beta1 (VLA-4) receptor | Integrin alpha4beta7 (LPAM-1) receptor | Integrin alpha5beta1 (VLA-5) receptor | Integrin alpha5beta3 receptor | Integrin alpha6beta1 Receptor | Integrin alpha6beta4 receptor | Integrin alpha7beta1 Receptor | Integrin alpha9beta1 receptor | Integrin alphaEbeta7 receptor | Integrin alphaLbeta2 (LFA-1) receptor | Integrin alphaMbeta2 (MAC-1) Receptor | Integrin alphavbeta1 | Integrin alphavbeta3 (vitronectin) receptor | Integrin alphavbeta5 receptor | Integrin alphavbeta6 receptor | Integrin alphavbeta8 Receptor | Integrin Receptor | Integrin-linked kinase | Interferon | Interferon-alpha (IFN-alpha) | Interferon-gamma Receptor | Interleukin 17 | Interleukin 21 receptor complex | Interleukin 23 complex (IL-23) | Interleukin 35 | Interleukin-1 | Interleukin-1 receptor-associated kinase (IRAK) | Interleukin-12 (IL-12) | Interleukin-18 Receptor Complex | Interleukin-27 (IL-27) Complex | Interleukin-39 (IL-39) | Interleukin-7 receptor | Intraflagellar transport complex | Intraflagellar transport complex A | Intraflagellar transport complex B | Intrinsic Tenase Complex | INTS1 | INTS10 | INTS11 | INTS12 | INTS13 | INTS14 | INTS15 | INTS2 | INTS3 | INTS4 | INTS4P1 | INTS4P2 | INTS5