OR14I1: Potential Drug Target and Biomarker for Neurological Disorders
OR14I1: Potential Drug Target and Biomarker for Neurological Disorders
Olfactory receptor family 14 (OR14) is a subfamily of the olfactory receptor family that plays a crucial role in human sensory function. OR14 is composed of two transmembrane proteins, OR14I1 and OR14I2, which differ in their extracellular loops and their potential docking partners. OR14I1 is a potential drug target and has been identified as a potential biomarker for various neurological and psychiatric disorders.
OR14I1 is a 14-kDa transmembrane protein that consists of a N-terminal cytoplasmic domain, a transmembrane segment, and a C-terminal cytoplasmic domain. The N-terminal cytoplasmic domain contains a putative G-protein-coupled receptor (GPCR) domain, which is known to interact with various signaling molecules. The transmembrane segment contains a variable region that includes a single transmembrane segment and a Golgi-associated region (GAR). The C-terminal cytoplasmic domain is a 21-kDa region that contains a putative GPCR domain, similar to the one found in OR11.
OR14I1 has been shown to play a crucial role in human sensory function, particularly in the sense of smell. OR14I1 is expressed in the olfactory system and is involved in the perception of various odors, including scents such as soap, spices, and flowers. OR14I1 is also involved in the regulation of the activity of other olfactory neurons, suggesting a role in the complex sense of smell.
OR14I1 has been identified as a potential drug target due to its involvement in various neurological and psychiatric disorders. For example, studies have shown that individuals with Alzheimer's disease (AD) have decreased expression of OR14I1 compared to healthy individuals. Additionally, individuals with ADHD have also been found to have decreased OR14I1 expression.
OR14I1 has also been shown to be involved in the regulation of various psychiatric disorders, such as depression and anxiety. Studies have shown that individuals with major depressive disorder (MDD) have decreased OR14I1 expression, while individuals with anxiety disorder have increased OR14I1 expression.
In addition to its involvement in neurological and psychiatric disorders, OR14I1 has also been shown to be involved in cancer progression. Studies have shown that individuals with breast cancer have decreased OR14I1 expression, which may contribute to the development and progression of cancer.
OR14I1 has also been identified as a potential biomarker for various neurological disorders. For example, studies have shown that individuals with Alzheimer's disease have decreased OR14I1 expression, which may be a potential indicator of the disease. Additionally, OR14I1 has been shown to be involved in the regulation of neurodegeneration, which may be a potential biomarker for various neurodegenerative disorders.
Despite its potential role in various neurological and psychiatric disorders, OR14I1 has not yet been fully characterized as a drug target or biomarker. Further research is needed to fully understand the role of OR14I1 in human sensory function and its potential as a drug target or biomarker.
In conclusion, Olfactory receptor family 14 (OR14) is a subfamily of the olfactory receptor family that plays a crucial role in human sensory function. OR14 is composed of two transmembrane proteins, OR14I1 and OR14I2, which differ in their extracellular loops and their potential docking partners. OR14I1 is a potential drug target and has been identified as a potential biomarker for various neurological and psychiatric disorders. Further research is needed to fully understand the role of OR14I1 in human sensory function and its potential as a drug target or biomarker.
Protein Name: Olfactory Receptor Family 14 Subfamily I Member 1
Functions: Odorant receptor
The "OR14I1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about OR14I1 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
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• its importance;
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• expression level;
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• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
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• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
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