MCM5: Chromatin Maintenance and Cancer-Related Protein (G4174)
MCM5: Chromatin Maintenance and Cancer-Related Protein
MCM5, also known as Minichromosome maintenance deficient protein 5, is a gene that encodes a protein that plays a crucial role in the proper functioning of chromatin. Chromatin is the complex of DNA, RNA, and proteins that make up the chromosomes. It is responsible for the packaging and storage of genetic information and is critical for the development and maintenance of the cell. MCM5 is a protein that helps to ensure that chromatin is properly maintained and that the cell has a stable genetic foundation.
MCM5 is a member of the Chromatin Maintenance subfamily, which is a group of proteins that help to ensure the stability of chromatin. These proteins work by interacting with specific DNA sequences and by doing so they can prevent the DNA from being removed or added in a process called \" homology-directed repair\" (HDR). MCM5 is unique among its kind as it is the only chromatin maintenance protein that is known to be involved in the process of homology-directed repair.
MCM5 is also involved in the regulation of the replication of the DNA. It plays a role in the proper formation of the replication complex, which is the set of proteins and RNA that are required for DNA replication. MCM5 helps to ensure that the replication complex is properly assembled and that the DNA replication process is reliable.
In addition to its role in chromatin maintenance and replication, MCM5 is also involved in the regulation of gene expression. It interacts with the RNA polymerase II (RNA-II), which is the enzyme that transscribes DNA into RNA. MCM5 helps to ensure that RNA-II is properly assembled and that it has access to the DNA it needs to transscribe RNA.
MCM5 is also a key player in the regulation of cell cycle progression. It helps to ensure that the cell cycle is properly regulated and that the cell spends the appropriate amount of time in each stage of the cell cycle. This is important for the proper functioning of the cell and for the development and maintenance of the cell.
MCM5 is also associated with a number of diseases, including cancer. It has been shown to be involved in the regulation of the development and progression of a number of cancers, including breast, ovarian, and colorectal cancer. of the immune response, which is important for the fight against cancer.
In conclusion, MCM5 is a protein that plays a crucial role in the proper functioning of chromatin and the regulation of the cell cycle. It is involved in the maintenance of the genetic foundation of the cell, the regulation of gene expression, and the regulation of cell cycle progression. MCM5 is also associated with a number of diseases, including cancer and it is a potential drug target. Further research is needed to fully understand the role of MCM5 in the regulation of the cell and to develop effective treatments for the diseases associated with its dysfunction.
Protein Name: Minichromosome Maintenance Complex Component 5
Functions: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:16899510). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425)
The "MCM5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MCM5 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
MCM6 | MCM7 | MCM8 | MCM8-MCM9 complex | MCM9 | MCMBP | MCMDC2 | MCOLN1 | MCOLN2 | MCOLN3 | MCPH1 | MCPH1-AS1 | MCPH1-DT | MCRIP1 | MCRIP2 | MCRS1 | MCTP1 | MCTP2 | MCTS1 | MCTS2 | MCU | MCUB | MCUR1 | MDC1 | MDFI | MDFIC | MDGA1 | MDGA2 | MDH1 | MDH1B | MDH2 | MDK | MDM1 | MDM2 | MDM4 | MDN1 | MDS2 | ME1 | ME2 | ME3 | MEA1 | MEAF6 | MEAF6P1 | MEAK7 | Mechanoelectrical transducer (MET) channel | Mechanosensitive Ion Channel | MECOM | MECOM-AS1 | MeCP1 histone deacetylase (HDAC) complex | MECP2 | MECR | MED1 | MED10 | MED11 | MED12 | MED12L | MED13 | MED13L | MED14 | MED14P1 | MED15 | MED15P8 | MED16 | MED17 | MED18 | MED19 | MED20 | MED21 | MED22 | MED23 | MED24 | MED25 | MED26 | MED27 | MED28 | MED29 | MED30 | MED31 | MED4 | MED4-AS1 | MED6 | MED7 | MED8 | MED9 | MEDAG | Mediator Complex | Mediator of RNA Polymerase II Transcription | MEF2A | MEF2B | MEF2C | MEF2C-AS1 | MEF2C-AS2 | MEF2D | MEFV | MEG3 | MEG8 | MEG9 | MEGF10 | MEGF11 | MEGF6
