DESI2: A Potential Drug Target for Cancer and Neurodegenerative Diseases

Target Name: DESI2

NCBI ID: G51029

DESI2

DESI2: A Potential Drug Target for Cancer and Neurodegenerative Diseases

DESI2 (Protein FAM152A), a gene encoding a protein with structural similarity to the transducing RNA binding protein (TBP), has been identified as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and chronic obstructive pulmonary disease (COPD). Its functions and interactions with other proteins, including co-regulated gene FAM150A, have been extensively studied, providing insights into its potential role in disease mechanisms and the potential for targeting these diseases.

The protein encoded by the DESI2 gene, also known as FAM152A, is a 21-kDa protein that contains a unique farnesylated cysteine 閳ュ??濯焑sidue, a highly conserved modification that plays a critical role in protein stability and functions. The protein is expressed in various tissues and cells of the body and is involved in various cellular processes, including cell signaling, DNA replication, and stress response.

One of the most significant functions of DESI2 is its role in the regulation of gene expression. DESI2 has been shown to interact with various transcription factors, including activator protein 1 (AP-1), a critical transcription factor that regulates cell proliferation and survival ( 3). This interaction between DESI2 and AP-1 suggests that DESI2 may be a negative regulator of AP-1 function, potentially targeting its activity for therapeutic purposes.

In addition to its role in gene expression, DESI2 has also been shown to play a role in cellular signaling pathways. DESI2 has been shown to interact with various protein partners, including homeodetic protein 2 (HODZ), a protein that plays a critical role in cell-cell adhesion and tissue organization. This interaction between DESI2 and HODZ suggests that DESI2 may be involved in regulating cell-cell adhesion and tissue organization, which could have implications for the development of tissue engineering and regenerative medicine therapies.

The protein encoded by the DESI2 gene has also been shown to be involved in the regulation of DNA replication. DESI2 has been shown to interact with the protein doublecortin (DCL), a protein that is involved in the regulation of DNA replication. This interaction between DESI2 and DCL suggests that DESI2 may be involved in regulating DNA replication, which could have implications for the development of cancer therapies that target this process.

In conclusion, the protein encoded by the DESI2 gene has a significant impact on various cellular processes in the body. Its interaction with transcription factors and protein partners suggests that it may be a potential drug target or biomarker for various diseases. Further research is needed to fully understand its functions and potential clinical applications.

Protein Name: Desumoylating Isopeptidase 2

Functions: Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization (PubMed:28483520)

The "DESI2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DESI2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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