DES: A Drug Target / Disease Biomarker (G1674)

Target Name: DES

NCBI ID: G1674

Content of Review Report on DES Target / Biomarker

DES

DES: A Drug Target / Disease Biomarker

DES, short for Deoxyribonucleic Acid, is a molecule that plays a crucial role in the structure and function of all living organisms. It is the foundation of heredity and contains the genetic information that is passed down from parent to offspring.

DES has also been identified as a potential drug target and biomarker for a variety of diseases, including cancer, HIV, and cardiovascular disease. Its unique structure and various functions make it an attractive target for drug developers because it is difficult to target and because it is involved in many different cellular processes that are important for the health and disease.

One of the reasons why DES is a promising drug target is its unique structure. DES is a double helix, which means that it consists of two separate strands of DNA that are twisted together to form a double helix. This structure makes it difficult to target the molecule with small molecules or antibodies because the molecule is so large and the targeting molecules have a hard time finding it.

Another reason why DES is a promising drug target is its involvement in many different cellular processes that are important for the health and disease. DES is involved in the replication of DNA, the transcription of DNA into RNA, and the regulation of gene expression. It is also involved in the immune response, cell signaling, and the regulation of cell growth.

DES's involvement in these processes makes it an attractive target for drugs that want to treat a wide range of diseases. For example, DES has been shown to be involved in the development of cancer, including breast, ovarian, and prostate cancers. It has also been linked to the development of cardiovascular disease, including heart failure, coronary artery spasms, and stroke.

In addition to its involvement in the development of cancer and cardiovascular disease, DES has also been shown to be involved in the regulation of pain. It has been shown to play a role in the development of chronic pain, including pain caused by conditions such as fibromyalgia and chronic pain disorders.

DES's potential as a drug target and biomarker also makes it an attractive target for research into neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. DES has been shown to be involved in the development of these conditions, and its unique structure and functions make it an attractive target for drugs that want to treat these conditions.

In conclusion, DES is a molecule that has the potential to be a drug target and biomarker for a wide range of diseases. Its unique structure and involvement in many different cellular processes make it an attractive target for drug developers. Further research is needed to fully understand the potential of DES as a drug target and biomarker.

Protein Name: Desmin

Functions: Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity)

The "DES Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DES comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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