DESI1: A Protein Involved in DNA-Binding and Cellular Processes

Target Name: DESI1

NCBI ID: G27351

DESI1

DESI1: A Protein Involved in DNA-Binding and Cellular Processes

DESI1 (DNA-binding endoplasmic protein 1) is a protein that is expressed in most tissues of the body. It is a 21-kDa protein that contains a PPPDE (peptidase domain containing 2) domain. The PPPDE domain is a structural domain that is characterized by a specific arrangement of amino acids that are involved in the catalytic mechanism of proteinases.

The PPPDE domain is responsible for the protein's catalytic activity and plays a key role in its function. The PPPDE domain is able to catalyze the hydrolysis of a specific peptide bond, which is the bond that connects two amino acids. This process is known as peptidase activity, and it allows the protein to break down and regulate the structure of proteins.

One of the unique features of DESI1 is its ability to interact with DNA. DESI1 is a DNA-binding protein, and it is able to bind to specific sequences of DNA with high affinity. This interaction between DESI1 and DNA allows it to participate in a variety of cellular processes, including gene regulation, DNA replication, and repair.

DESI1 has been shown to play a role in the regulation of gene expression in various organisms, including humans. For example, DESI1 has been shown to be involved in the regulation of the gene expression that is responsible for the production of the protein known as EGFR. This protein is a key regulator of cell growth and division, and it is involved in the development of many types of cancer.

DESI1 is also involved in the regulation of DNA replication. It has been shown to play a role in the repair of DNA damage, which is a critical process that occurs in the cell after exposure to environmental stressors or during the course of cellular division. This ability to repair DNA damage makes DESI1 an important protein for the regulation of cell health and survival.

In addition to its role in gene regulation, DESI1 is also involved in the regulation of protein function. It has been shown to interact with various protein substrates and to play a role in the regulation of protein activity. This interaction between DESI1 and other proteins allows it to regulate the activity of these proteins and to contribute to the overall regulation of cellular processes.

DESI1 is also a potential drug target. Its ability to interact with DNA and to regulate gene expression makes it an attractive target for small molecule inhibitors. For example, researchers have developed compounds that are designed to inhibit DESI1's catalytic activity and to block its interaction with DNA. These compounds have been shown to be effective in a variety of cellular assays, including cell-based assays and in animal models of cancer.

In addition to its potential as a drug target, DESI1 is also a potential biomarker. Its ability to interact with DNA and to regulate gene expression makes it an attractive candidate for use as a genetic marker. For example, researchers have used DESI1 as a marker to study the effects of drugs on cancer cell growth and division. They have found that DESI1 levels are significantly altered in response to these drugs, and that these changes can be used to monitor the effectiveness of these drugs in animal models of cancer.

Overall, DESI1 is a protein that is involved in a variety of cellular processes and has been shown to play a role in the regulation of gene expression, DNA replication, and protein function. Its ability to interact with DNA and to regulate these processes makes it an attractive target for small molecule inhibitors and for use as a biomarker. Further research is needed to fully understand the role of DESI1 in cellular processes and its potential as a drug and biomarker.

Protein Name: Desumoylating Isopeptidase 1

Functions: Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity (By similarity). Desumoylates ZBTB46 (By similarity). Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234)

The "DESI1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DESI1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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