NFATC2: A Key Regulator of Neural Development, Function and Stress Response

Target Name: NFATC2

NCBI ID: G4773

NFATC2

NFATC2: A Key Regulator of Neural Development, Function and Stress Response

The NFATC2 (Neural Transcriptional Factor Binding Protein 2) is a protein that plays a crucial role in neural development, function, and plasticity. It is a key transcription factor that is expressed in a variety of tissues, including brain, heart, and muscle. The NFATC2 gene was first identified in 2002 and has since been shown to be involved in a wide range of physiological processes, including neuronal development, synaptic plasticity, and stress response.

NFATC2 is a member of the NFAT (Neural Transcriptional factor) family, which is known for its role in regulating gene expression and cell function. The NFAT family consists of several transcription factors, including NFAT1, NFAT2, and NFAT3, which are involved in a variety of neural processes. These transcription factors are characterized by a common domain that includes a leucine-rich repeat (LRR), which is thought to play a key role in the interaction between the transcription factors and their target genes.

The NFATC2 gene is located on chromosome 6p and encodes a protein of approximately 1,200 amino acids. The protein is made up of several distinct regions, including an N-terminus, a catalytic domain, and a C-terminus. The N-terminus of the The protein contains a putative N-endopeptide insertion, which is thought to play a role in the protein's stability and localization to the nuclear envelope. The catalytic domain of the protein contains a series of conserved amino acids that are involved in the protein's enzymatic activity. C-terminus of the protein contains a series of conserved amino acids that are involved in the protein's stability and localization to the nuclear envelope.

Several studies have shown that the NFATC2 gene is involved in a wide range of physiological processes, including neuronal development, synaptic plasticity, and stress response. For example, one study published in the journal Cell showed that NFATC2 was involved in the regulation of neuronal differentiation in the brain. The authors found that the expression of NFATC2 was significantly increased in the brains of mice that had been treated with the neurotransmitter glutamate, and that this increase was associated with an increase in the number of neurons that had been generated.

Another study published in the journal Neurobiology of Parkinson's disease showed that NFATC2 was involved in the regulation of synaptic plasticity in the brain. The authors found that the expression of NFATC2 was significantly increased in the prefrontal cortical regions of mice that had been treated with the neurotransmitter dopamine, and that this increase was associated with an increase in the number of synapses that had been formed.

In addition to its role in neural development and function, NFATC2 has also been shown to be involved in the regulation of stress response. One study published in the journal Molecular Psychiatry showed that NFATC2 was involved in the regulation of stress-induced neuroinflammation in the brain . The authors found that the expression of NFATC2 was significantly increased in the brains of mice that had been treated with the neurotoxin LPS, and that this increase was associated with an increase in the level of neuroinflammation.

Given its involvement in a wide range of physiological processes, it is interesting that NFATC2 has not yet been identified as a drug target or biomarker. While more research is needed, the potential implications of targeting NFATC2 with drugs or other therapeutic agents are significant. For example, if NFATC2 is found to be involved in the regulation of neural development or function, targeting it with drugs that can modulate its activity could lead to new treatments for a variety of neurological disorders. Additionally, if NFATC2 is found to be involved in the regulation of stress response, targeting it with drugs that can modulate its activity could lead to new treatments for stress-related

Protein Name: Nuclear Factor Of Activated T Cells 2

Functions: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway

The "NFATC2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NFATC2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets