NUP98: A Potential Drug Target and Biomarker for Nuclear Pore Complex

Target Name: NUP98

NCBI ID: G4928

NUP98

NUP98: A Potential Drug Target and Biomarker for Nuclear Pore Complex

Nuclear pore complex (NPC) proteins play a crucial role in the regulation of nuclear traffic, a process that controls the movement of materials into and out of the nucleus. One of the most well-known NPC proteins is Nup98, a protein that is expressed in various cell types and is involved in the NPC export of nucleosomes, the basic unit of chromatin.

The NPC is a complex of proteins that form a framework through which the nuclear pore, a protein structure located in the nucleus, opens and allows material to come and go. The NPC is composed of numerous subunits, including Nup94, Nup96, and Nup98, among others. These subunits form a repeating pattern of 尾-helices, which give the protein its characteristic structure.

Nup98 is a 22-kDa protein that is expressed in various cell types, including muscle, nerve, and epithelial cells. It is one of the key components of the NPC and is involved in the export of nucleosomes from the nucleus to the cytoplasm. Nup98 functions by forming a complex with the nucleosome exportase, a protein that uses the NPC to transport nucleosomes to the cytoplasm.

One of the key functions of Nup98 is its role in the regulation of the size of the nucleosome. The nucleosome is the basic unit of chromatin and is composed of a core of DNA wrapped in a protein shell. The size of the nucleosome can be regulated by various factors, including the amount of DNA in the cell, the level of transcription, and the activity of the nuclear export machinery. Nup98 is involved in the regulation of these factors, which in turn affects the size of the nucleosome.

In addition to its role in regulating the size of the nucleosome, Nup98 is also involved in the regulation of the nuclear pore. The nuclear pore is a protein structure located in the nucleus that allows the movement of materials into and out of the nucleus. Nup98 functions by forming a complex with the nucleosome exportase, which helps to regulate the size and distribution of nucleosomes in the cytoplasm.

The NPC exportase is a protein that uses the NPC to transport nucleosomes to the cytoplasm. Nup98 is involved in this process by forming a complex with the nucleosome exportase, which allows the exportase to use the NPC to transport nucleosomes to the cytoplasm. The level of nucleosome export is regulated by various factors, including the level of DNA in the cell, the level of transcription, and the activity of the nuclear export machinery. Nup98 is involved in the regulation of these factors, which in turn affects the level of nucleosome export and the size of the nucleosome.

Nup98 is also involved in the regulation of the cytoplasmic environment. The cytoplasmic environment is the space between the nucleus and the cytoplasm, and it plays a crucial role in the regulation of various cellular processes, including the transport of nutrients, waste products, and signaling molecules. Nup98 is involved in the regulation of the cytoplasmic environment by controlling the movement of nucleosomes into and out of the cytoplasm.

In conclusion, Nup98 is a protein that is involved in the regulation of various cellular processes, including the regulation of the size and distribution of nucleosomes in the nucleus, the regulation of the nuclear pore, and the regulation of the cytoplasmic environment. As a potential drug target and biomarker, Nup98 is a promising target for future research in the field of nuclear

Protein Name: Nucleoporin 98 And 96 Precursor

Functions: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134)

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