DHH Protein: A Potential Drug Target and Biomarker (G50846)

Target Name: DHH

NCBI ID: G50846

Content of Review Report on DHH Target / Biomarker

DHH

DHH Protein: A Potential Drug Target and Biomarker

The Desert hedgehog (DHH) protein is a key regulator of cell proliferation and survival in various tissues, including the liver, pancreas, and gastrointestinal tract. It is a small non-coding RNA molecule that plays a crucial role in the development and maintenance of these organs, as well as in tissue repair and regeneration. The DHH protein is highly conserved across species, and its expression is often used as a biomarker for various diseases, including cancer, obesity, and neurodegenerative disorders.

DHH Protein as a Drug Target

The DHH protein is a potential drug target in various diseases due to its unique structure and biochemical properties. One of its key advantages is its ability to interact with a variety of protein substrates, including casein kinase (CK) 2, which is a critical regulator of cell proliferation and survival. The DHH protein has been shown to play a positive role in the regulation of CK2 activity, which can lead to increased cell proliferation and survival.

In addition to its role in cell proliferation, the DHH protein is also involved in the regulation of cell apoptosis (programmed cell death). DHH has been shown to induce cell apoptosis in various cell types, including cancer cells, which may be a potential mechanism for its anti-cancer properties.

The DHH protein has also been shown to play a role in the regulation of inflammation and immune responses. It has been shown to reduce the production of pro-inflammatory cytokines in response to various stimuli, which may have implications for the regulation of autoimmune diseases.

DHH as a Biomarker

The DHH protein is a potential biomarker for various diseases due to its unique expression patterns and biochemical properties. Its expression is often increased in diseases such as cancer, obesity, and neurodegenerative disorders, which may be useful for the diagnosis and monitoring of these diseases.

In addition to its use as a drug target, the DHH protein is also a potential biomarker for cancer. The DHH protein has been shown to be downregulated in various types of cancer, including breast, lung, and colon cancer. This may be a potential target for cancer therapies that target the DHH protein.

The DHH protein is also an attractive biomarker for obesity. Obesity is a complex disease that is associated with a variety of health problems, including cardiovascular disease, diabetes, and certain cancers. The DHH protein has been shown to be involved in the regulation of obesity, and may be a potential target for therapies aimed at reducing obesity.

In addition to its potential as a cancer and obesity biomarker, the DHH protein may also be a useful biomarker for neurodegenerative disorders. The DHH protein has been shown to be involved in the regulation of neurodegenerative disorders, and may be a potential target for therapies aimed at treating these disorders.

Conclusion

The DHH protein is a unique and conserved non-coding RNA molecule that plays a crucial role in the development and maintenance of various tissues, including the liver, pancreas, and gastrointestinal tract. Its expression is often increased in diseases such as cancer, obesity, and neurodegenerative disorders, and may be a potential drug target and biomarker for these diseases. Further research is needed to fully understand the role of the DHH protein in these diseases and to develop effective therapies aimed at targeting it.

Protein Name: Desert Hedgehog Signaling Molecule

Functions: The C-terminal part of the desert hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (N-product and C-product) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Functions in cell-cell mediated juxtacrine signaling (PubMed:24342078). Promotes endothelium integrity (PubMed:33063110). Binds to PTCH1 receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes in endothelial cells (PubMed:33063110). In Schwann cells, controls the development of the peripheral nerve sheath and the transition of mesenchymal cells to form the epithelium-like structure of the perineurial tube (By similarity)

The "DHH Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DHH comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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