SLC4A2: Anion Exchange Protein and Potential Drug Target (G6522)

Target Name: SLC4A2

NCBI ID: G6522

SLC4A2

SLC4A2: Anion Exchange Protein and Potential Drug Target

SLC4A2 (Anion exchange protein 2) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and lungs. It is a member of the SLC4A family, which is known for its role in transporting various molecules across cell membranes. One of the unique features of SLC4A2 is its ability to facilitate anion exchange, which is the process by which positively charged ions are exchanged for negatively charged ions.

SLC4A2 has been shown to play a role in a variety of physiological processes in the body. For example, it has been shown to be involved in the regulation of ion homeostasis in the brain, heart, and lungs. It has also been shown to be involved in the regulation of cellular signaling processes, such as cell division and apoptosis.

In addition to its role in regulation, SLC4A2 has also been shown to be a potential drug target. Researchers have identified several potential drug candidates that target SLC4A2, and are currently in the process of testing these compounds in clinical trials. If these compounds are successful in treating diseases associated with SLC4A2 dysfunction, they could potentially be used to treat a wide range of conditions, including heart failure, neurodegenerative diseases, and respiratory disorders.

SLC4A2 is also a potential biomarker for a variety of diseases. Its ability to facilitate anion exchange makes it a promising candidate for the diagnosis and monitoring of certain conditions, such as hyponatremia (low serum sodium levels) and hyperkalemia (high serum potassium levels). Additionally, SLC4A2 levels have been shown to be elevated in a variety of diseases, including neurodegenerative diseases and cancer. These findings suggest that SLC4A2 may be a useful biomarker for the diagnosis and treatment of these diseases.

Overall, SLC4A2 is a complex and highly versatile protein that has the potential to be a drug target and biomarker. Further research is needed to fully understand its role in various physiological processes and to develop effective treatments for diseases associated with its dysfunction.

Protein Name: Solute Carrier Family 4 Member 2

Functions: Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMed:34668226). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity)

The "SLC4A2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLC4A2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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