SLC3A1: Neutral and Basic Amino Acid Transport Protein (G6519)

Target Name: SLC3A1

NCBI ID: G6519

SLC3A1

SLC3A1: Neutral and Basic Amino Acid Transport Protein

SLC3A1 (Neutral and basic amino acid transport protein rBAT) is a protein that plays a crucial role in the transport of neutral and basic amino acids across cell membranes. It is a member of the SLC3A family, which includes several other proteins involved in the transport of a variety of different molecules across cell membranes. SLC3A1 is expressed in most tissues and cells of the body and is involved in the delivery of a wide range of amino acids, including alanine, aspartic acid, glutamic acid, and aspartic acid.

SLC3A1 is a transmembrane protein, which means that it spans the cell membrane and is involved in the delivery of substances across the membrane. It is made up of four distinct subunits, which are arranged in a specific sequence to form the protein structure. These subunits include an N-terminal transmembrane region, a catalytic region, and two C-terminal cytoplasmic regions. The N-terminal transmembrane region contains a unique protein called N-terminal transmembrane domain (NMD), which is involved in the formation of the protein structure and has been shown to play a role in the regulation of the transport of certain amino acids.

The catalytic region of SLC3A1 is responsible for the transport of the amino acids across the membrane. It consists of a unique protein called Glutamic acid-rich region (GAR) and is the site of the protein's catalytic activity. The GAR region is composed of multiple discrete regions, including a catalytic active site and a binding site for the amino acid transporter. The catalytic active site is the site of the protein's catalytic activity and is responsible for the binding and transport of the amino acids. The binding site is the site where the amino acid is bound and is responsible for the regulation of the transport process.

The cytoplasmic regions of SLC3A1 are involved in the regulation of the transport of the amino acids across the membrane. The N-terminal cytoplasmic region is involved in the regulation of the overall expression of the protein and has been shown to play a role in the regulation of the transport of certain amino acids. The C-terminal cytoplasmic region is involved in the regulation of the binding of the amino acids to the protein and has been shown to play a role in the regulation of the transport of certain amino acids.

SLC3A1 is involved in the delivery of a wide range of amino acids across cell membranes. It is expressed in most tissues and cells of the body and is involved in the transport of alanine, aspartic acid, glutamic acid, and aspartate. It is also involved in the transport of other molecules, including asparagine and asparagine. The protein is also involved in the regulation of the transport of other molecules across cell membranes, including glucose and nucleotides.

SLC3A1 is a potential drug target and may be used as a biomarker for a variety of diseases. Its involvement in the delivery of amino acids across cell membranes makes it a potential target for drugs that are designed to disrupt the transport of amino acids across cell membranes. The regulation of the transport of amino acids across cell membranes is also a potential target for drugs that are designed to regulate the activity of SLC3A1.

In conclusion, SLC3A1 (Neutral and basic amino acid transport protein rBAT) is a protein that plays a crucial role in the transport of neutral and basic amino acids across cell membranes. It is a member of the SLC3A family and is expressed in most tissues and cells of the body. SLC3A1 is involved in the delivery of a wide range of amino acids across cell membranes and is a potential drug target and biomarker for a variety of diseases. Further research is needed to fully understand the role of SLC3A1 in

Protein Name: Solute Carrier Family 3 Member 1

Functions: Associates with SLC7A9 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1 (PubMed:8663357, PubMed:16825196, PubMed:32817565, PubMed:32494597, PubMed:11318953, PubMed:7686906, PubMed:8486766, PubMed:8663184). Acts as a chaperone that facilitates biogenesis and trafficking of functional SLC7A9-SLC3A1 heteromers to the plasma membrane. SLC7A9-SLC3A1 transporter has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids (PubMed:16825196, PubMed:32817565, PubMed:32494597, PubMed:11318953, PubMed:7686906, PubMed:8486766, PubMed:8663184). Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine (PubMed:11318953, PubMed:7686906, PubMed:8486766, PubMed:8663184). Required for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in renal proximal tubules (PubMed:10588648, PubMed:16609684)

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