SLC39A8: A Critical Gene for Understanding Cellular Functions

Target Name: SLC39A8

NCBI ID: G64116

SLC39A8

SLC39A8: A Critical Gene for Understanding Cellular Functions

SLC39A8 is a gene that encodes a protein known as solute carrier family 39 member A (SLC39A8). The SLC39A8 protein is a transmembrane protein that is expressed in various tissues and cells throughout the body. It plays a critical role in the transport of various substances including ions, nutrients, and waste products across cell membranes.

One of the unique aspects of the SLC39A8 protein is its structure and its role in various physiological processes. The SLC39A8 protein is composed of 184 amino acid residues and has a calculated molecular mass of 21.1 kDa. It has a single transmembrane region and five intracellular loops. The protein has a hydrophobic region at its extracellular side and a hydrophilic region at its intracellular side.

The SLC39A8 protein is expressed in various tissues and cells throughout the body, including the brain, heart, liver, kidney, and intestine. It is also expressed in various cell types, including neurons, astrocytes, endothelial cells, and epithelial cells. The protein is involved in the transport of various substances across cell membranes, including ions, nutrients, and waste products.

One of the key functions of the SLC39A8 protein is its role in maintaining the proper balance of ions and nutrients in various body tissues. For example, it is involved in the transport of sodium and potassium ions across cell membranes, which is essential for maintaining the normal levels of these ions in the body. The protein is also involved in the transport of glucose and other nutrients across cell membranes, which is essential for maintaining the normal levels of these nutrients in the body.

In addition to its role in the transport of ions and nutrients, the SLC39A8 protein is also involved in the regulation of various physiological processes. For example, it is involved in the regulation of blood pressure, which is essential for maintaining the proper functioning of the cardiovascular system. The protein is also involved in the regulation of the production of urine, which is essential for maintaining the proper levels of waste products in the body.

The SLC39A8 protein is also involved in the regulation of various cellular processes, including cell signaling, cell division, and cell adhesion. For example, the protein is involved in the regulation of the production of neurotransmitters, which are essential for signaling communication between neurons. The protein is also involved in the regulation of cell division, which is essential for the growth and development of various tissues and organs.

In conclusion, SLC39A8 is a gene that encodes a protein with critical functions in various physiological processes. The protein plays a vital role in the transport of ions and nutrients across cell membranes and is also involved in the regulation of various physiological processes, including blood pressure, urine production, and cell signaling, division, and adhesion. As a result, SLC39A8 is a potential drug target and a biomarker for various diseases, including cardiovascular disease, neurodegenerative diseases, and urologic diseases. Further research is needed to fully understand the role of SLC39A8 in various physiological processes and to develop effective treatments for diseases associated with its dysfunction.

Protein Name: Solute Carrier Family 39 Member 8

Functions: Electroneutral divalent metal cation:bicarbonate symporter of the plasma membrane mediating the cellular uptake of zinc and manganese, two divalent metal cations important for development, tissue homeostasis and immunity (PubMed:12504855, PubMed:22898811, PubMed:23403290, PubMed:29337306, PubMed:26637978, PubMed:29453449). Transports an electroneutral complex composed of a divalent metal cation and two bicarbonate anions or alternatively a bicarbonate and a selenite anion (PubMed:27166256, PubMed:31699897). Thereby, it also contributes to the cellular uptake of selenium, an essential trace metal and micronutrient (PubMed:27166256). Also imports cadmium a non-essential metal which is cytotoxic and carcinogenic (PubMed:27466201). May also transport iron and cobalt through membranes (PubMed:22898811). Through zinc import, indirectly regulates the metal-dependent transcription factor MTF1 and the expression of some metalloproteases involved in cartilage catabolism and also probably heart development (PubMed:29337306). Also indirectly regulates the expression of proteins involved in cell morphology and cytoskeleton organization (PubMed:29927450). Indirectly controls innate immune function and inflammatory response by regulating zinc cellular uptake which in turn modulates the expression of genes specific of these processes (PubMed:23403290, PubMed:28056086). Protects, for instance, cells from injury and death at the onset of inflammation (PubMed:18390834). By regulating zinc influx into monocytes also directly modulates their adhesion to endothelial cells and arteries (By similarity). Reclaims manganese from the bile at the apical membrane of hepatocytes, thereby regulating the activity of the manganese-dependent enzymes through the systemic levels of the nutrient (PubMed:28481222). Also participates in manganese reabsorption in the proximal tubule of the kidney (PubMed:26637978). By mediating the extracellular uptake of manganese by cells of the blood-brain barrier, may also play a role in the transport of the micronutrient to the brain (PubMed:26637978, PubMed:31699897). With manganese cellular uptake also participates in mitochondrial proper function (PubMed:29453449). Finally, also probably functions intracellularly, translocating zinc from lysosome to cytosol to indirectly enhance the expression of specific genes during TCR-mediated T cell activation (PubMed:19401385)

The "SLC39A8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLC39A8 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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