SLC44A4: A Choline Transporter-Like Protein as a Drug Target and Biomarker

Target Name: SLC44A4

NCBI ID: G80736

SLC44A4

SLC44A4: A Choline Transporter-Like Protein as a Drug Target and Biomarker

Introduction

SLC44A4 (Choline transporter-like protein 4 isoform 3) is a protein that has been identified as a potential drug target and biomarker for various neurological and psychiatric disorders. It is a member of the SLC44 family, which includes several related proteins that are involved in SLC44A4 is expressed in various tissues and cell types, including the brain, and has been shown to play a role in the transport of choline compounds, such as the neurotransmitter acetylcholine.

The Role of SLC44A4 in neuroregulation

SLC44A4 is involved in the transport of choline compounds, including acetylcholine, a neurotransmitter that is involved in memory, attention, and cognitive function. Choline compounds have been shown to play a crucial role in the development and maintenance of neural circuits, and alterations in their levels or function have been implicated in a wide range of neuropsychiatric and neurological disorders. SLC44A4 has been shown to be involved in the regulation of choline compound transport in the brain, and may be a potential drug target for these disorders.

SLC44A4 as a drug target

SLC44A4 has been identified as a potential drug target for various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. These disorders are characterized by the progressive loss of nerve cells and the formation of aggregates of neurotransmitters, including acetylcholine. By Targeting SLC44A4, researchers may be able to improve the transport of choline compounds in the brain and reduce the formation of neurotransmitter aggregates, which have been shown to contribute to the development and progression of these disorders.

SLC44A4 as a biomarker

In addition to its potential as a drug target, SLC44A4 has also been identified as a potential biomarker for various neurological and psychiatric disorders. The ability of SLC44A4 to transport choline compounds may make it an attractive target for diagnostic tests for these disorders. For example, SLC44A4 has been shown to be involved in the regulation of the levels of acetylcholine in the brain, and alterations in acetylcholine levels have been implicated in the development of Alzheimer's disease. By measuring the levels of SLC44A4 in brain tissue or fluids, researchers may be able to diagnose Alzheimer's disease or other disorders associated with the progressive loss of nerve cells.

Conclusion

SLC44A4 is a protein that has been shown to play a role in the transport of choline compounds in the brain. Its involvement in this process makes it a potential drug target for various neurological and psychiatric disorders. Additionally, SLC44A4 has also been identified as a potential biomarker for these disorders, with the ability to transport choline compounds may make it an attractive target for diagnostic tests. Further research is needed to fully understand the role of SLC44A4 in neural function and the development of neurological and psychiatric disorders.

Protein Name: Solute Carrier Family 44 Member 4

Functions: Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity) (PubMed:23651124, PubMed:28013291). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis (PubMed:24379411)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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