SLC4A11: Potential Drug Target Or Biomarker (G83959)

Target Name: SLC4A11

NCBI ID: G83959

SLC4A11

SLC4A11: Potential Drug Target Or Biomarker

SLC4A11, also known as SLC4A11 gene or SLC4A11 protein, is a member of the Sodium Chloride Transporter family. It is a protein that is expressed in various tissues and cells throughout the body, including the brain, heart, and gastrointestinal tract. SLC4A11 plays a crucial role in the transport of sodium ions into cells, which is essential for many physiological processes, including muscle and nerve function, nerve signaling, and cell signaling.

SLC4A11 has also been identified as a potential drug target or biomarker. Researchers have shown that inhibiting SLC4A11 can cause a range of physiological effects, including muscle and nerve dysfunction, altered brain activity, and an increased risk of certain diseases. These effects make SLC4A11 an attractive target for drug development, particularly for treating conditions that involve muscle or nerve dysfunction, such as spinal cord injuries, multiple sclerosis, and neurodegenerative diseases.

In addition to its potential as a drug target, SLC4A11 has also been shown to be a valuable biomarker for certain diseases. For example, studies have shown that SLC4A11 levels are elevated in the brains of individuals with Alzheimer's disease, which is a leading cause of dementia. Additionally, SLC4A11 has been shown to be elevated in the blood of individuals with Parkinson's disease, another neurodegenerative disorder. These findings suggest that SLC4A11 may be a useful biomarker for the diagnosis and progression of certain neurodegenerative diseases.

SLC4A11 has also been shown to play a role in the regulation of ion channels in cells. In particular, SLC4A11 is involved in the regulation of the delayed rectifier channels, which are responsible for the rapid and slow transitions that occur during muscle and nerve contractions. By modulating the activity of these channels, SLC4A11 helps to regulate the electrical activity of muscles and nerves, which is essential for proper function.

In conclusion, SLC4A11 is a protein that is expressed in a variety of tissues and cells throughout the body. It plays a crucial role in the transport of sodium ions into cells and has been identified as a potential drug target or biomarker for a range of physiological processes, including muscle and nerve dysfunction, neurodegenerative diseases, and ion channel regulation. Further research is needed to fully understand the role of SLC4A11 in these processes and to develop effective treatments for the disorders that are associated with its dysfunction.

Protein Name: Solute Carrier Family 4 Member 11

Functions: Multifunctional transporter with an impact in cell morphology and differentiation. In the presence of borate B(OH)4(-), acts as a voltage-dependent electrogenic Na(+)-coupled B(OH)4(-) cotransporter controlling boron homeostasis (PubMed:15525507). At early stages of stem cell differentiation, participates in synergy with ITGA5-ITGB1 and ITGAV-ITGB3 integrins and BMPR1A to promote cell adhesion and contractility that drives differentiation toward osteogenic commitment while inhibiting adipogenesis (By similarity). In the absence of B(OH)4(-), acts as a Na(+)-coupled OH(-) or H(+) permeable channel with implications in cellular redox balance (PubMed:15525507, PubMed:28642546). Regulates the oxidative stress response in corneal endothelium by enhancing antioxidant defenses and protecting cells from reactive oxygen species (PubMed:28642546). In response to hypo-osmotic challenge, also acts as water permeable channel at the basolateral cell membrane of corneal endothelial cells and facilitates transendothelial fluid reabsorption in the aqueous humor (PubMed:31273259, PubMed:25007886, PubMed:23813972). In the presence of ammonia, acts as an electrogenic NH3/H(+) cotransporter and may play a role in ammonia transport and reabsorption in renal Henle's loop epithelium (PubMed:27581649)

The "SLC4A11 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLC4A11 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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