ING4: A Promising Brain Protein as a Drug Target and Biomarker

Target Name: ING4

NCBI ID: G51147

ING4

ING4: A Promising Brain Protein as a Drug Target and Biomarker

Introduction

The brain is a complex and dynamic organ that plays a crucial role in the development, growth, and maintenance of human health and wellbeing. It is home to an vast array of proteins, many of which are involved in various neural functions. One such protein is ING4, which is a key regulator of cell survival and proliferation in the brain.

ING4: Structural and Functional Characterization

ING4 is a non-coding RNA protein that is expressed in various tissues and organs, including the brain. It is highly conserved across different species, and its protein structure is highly conserved among different ING4 isoforms. ING4 has a unique molecular architecture, with a 194 amino acid long extracellular domain and a 60 amino acid long intracellular domain. The extracellular domain is involved in various interactions with other proteins, while the intracellular domain is involved in protein-protein interactions and regulation of cellular processes.

ING4 is involved in various cellular processes, including cell survival, proliferation, migration, and angiogenesis. It has been shown to play a role in the regulation of neuronal excitability, synaptic plasticity, and neurotransmitter release. ING4 has also been shown to be involved in the regulation of cell cycle progression, apoptosis, and autophagy.

ING4 as a Drug Target

ING4 is a promising drug target due to its unique structure and function. The intracellular domain of ING4 contains several potential binding sites that make it a potential target for small molecules. In addition, the extracellular domain has been shown to interact with various proteins, including Plasmin (ApoA1) and EGFR.

One of the most promising strategies for targeting ING4 is the use of small molecules that can modulate its intracellular domain activity. One such class of small molecules is the aryl hydrocarbon receptor (CAR) agonist. These molecules have been shown to activate the CAR receptor , which can then lead to the inhibition of ING4 protein activity.

ING4 as a Biomarker

ING4 has also been shown to be a potential biomarker for various neurological and psychiatric disorders. For example, ING4 has been shown to be involved in the regulation of neurotransmitter release in the brain, and alterations in ING4 expression have been observed in various psychiatric and psychiatric disorders. disorders.

ING4 has also been shown to be involved in the regulation of cell apoptosis, which is a crucial aspect of neurodegeneration and disease. Studies have shown that ING4 can induce cell apoptosis in various cellular models, including neurotransmitter release and neurotoxicity. This suggests that ING4 may play a role in the development and progression of neurodegenerative diseases.

Conclusion

ING4 is a unique and highly conserved protein that is involved in various cellular processes in the brain. Its intracellular domain activity makes it a potential target for small molecules, and its role in the regulation of cell survival and apoptosis makes it a promising biomarker for various neurological and psychiatric disorders. Further research is needed to fully understand the role of ING4 in neural function and disease.

Protein Name: Inhibitor Of Growth Family Member 4

Functions: Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653). Through chromatin acetylation it may function in DNA replication (PubMed:16387653). May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed:15251430, PubMed:15528276). Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed:15029197). May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed:15029197). Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed:15897452). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity)

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