ATP6V1D: A Potential Drug Target for Vacuolar Proton Pump Subunit D

Target Name: ATP6V1D

NCBI ID: G51382

ATP6V1D

ATP6V1D: A Potential Drug Target for Vacuolar Proton Pump Subunit D

Introduction

ATP6V1D (ATP-dependent vacuolar proton pump subunit D) is a protein that plays a crucial role in the function of the endoplasmic reticulum (ER) and vacuolar system. It is a subunit of the ATP-dependent proton pump, which is responsible for pumping The proton gradient goes from inside the cell to outside the cell, thereby maintaining the ion balance inside and outside the cell. ATP6V1D plays a key role in ion balance inside and outside cells, and its dysfunction may lead to a variety of diseases, including neurological diseases, kidney diseases, and tumors. Therefore, studying the function and mechanism of ATP6V1D has important clinical value for the treatment of these diseases.

Structure and function of ATP6V1D

ATP6V1D is a protein with a diameter of approximately 300 tracts and consists of 451 amino acids. It is located inside the cell, mainly on the outer surface of the cell membrane. ATP6V1D is a dimer composed of two subunits, each containing a transmembrane 伪-helix and an intracellular 尾-coil.

The main function of ATP6V1D is as ATP-dependent vacuolar proton pump subunit D, participating in the regulation of ion balance inside and outside the cell. Within cells, ATP6V1D maintains intracellular acid-base balance by pumping H+ ions across the cell membrane. Outside the cell, ATP6V1D reduces the acidity of the extracellular fluid by binding to H+ ions, thereby maintaining the acid-base balance of the extracellular fluid.

Pharmacological significance of ATP6V1D

ATP6V1D is a potential drug target because it plays a key role in maintaining ion balance inside and outside the cell. Many studies have shown that inhibiting the function of ATP6V1D can treat a variety of diseases, including neurological diseases, kidney diseases, and tumors.

First, inhibiting the function of ATP6V1D can be used to treat neurological diseases, such as Parkinson's disease and Alzheimer's disease. Both Parkinson's disease and Alzheimer's disease are related to neurodegeneration, and neurodegeneration is closely related to dysfunction of ATP6V1D. Research shows that inhibiting the function of ATP6V1D can reduce the apoptosis of nerve cells and improve the survival and function of nerve cells, thereby potentially treating Parkinson's disease and Alzheimer's disease.

Secondly, inhibiting the function of ATP6V1D can be used to treat kidney diseases, such as diabetes and renal insufficiency. Diabetes and renal insufficiency are both related to the imbalance of ion balance within the kidney, and ATP6V1D plays a key role in maintaining ion balance inside and outside cells. Studies have shown that inhibiting the function of ATP6V1D can improve the absorption and utilization of glucose by the renal tubules, reduce the concentration of H+ ions in the renal tubules, thereby improving renal function and potentially treating diabetes and renal insufficiency.

Finally, inhibiting the function of ATP6V1D can be used to treat diseases such as tumors. The growth and metastasis of tumor cells are related to the imbalance of ion balance inside and outside the cell, and ATP6V1D plays a key role in maintaining the ion balance inside and outside the cell. Studies have shown that inhibiting the function of ATP6V1D can inhibit the growth and metastasis of tumor cells, thereby potentially treating tumors.

Summarize

ATP6V1D is an important protein that plays a key role in maintaining ion balance inside and outside cells. Its dysfunction is closely related to a variety of diseases, including neurological diseases, kidney diseases, and tumors. Therefore, inhibiting the function of ATP6V1D can be used to treat these diseases, including Parkinson's disease, Alzheimer's disease, diabetes, renal insufficiency, and tumors.

Protein Name: ATPase H+ Transporting V1 Subunit D

Functions: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (PubMed:21844891)

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