Understanding The Role of CALML5 in Synaptic Plasticity (G51806)

Target Name: CALML5

NCBI ID: G51806

CALML5

Understanding The Role of CALML5 in Synaptic Plasticity

CALML5, short for callosal-marginless activity-sensitive learning module 5, is a protein that is expressed in the brain and plays a crucial role in the development and maintenance of synaptic plasticity, which is the ability of the brain to learn and adapt over time. Synaptic plasticity is critical for the formation of new memories, learning, and problem-solving, and is associated with a wide range of cognitive functions.

CALML5 is a transmembrane protein that is located in the dendrites of neurons. It is composed of four structural domains: an N-terminus, a transmembrane domain, a cytoplasmic domain, and a C-terminus. The N-terminus of CALML5 contains a putative G protein-coupled receptor (GPCR) domain, which is known for its role in signaling and modulation of gene expression. The transmembrane domain of CALML5 is made up of a variable number of伪-helices, which are responsible for the protein's ability to interact with various signaling molecules and for its structural stability. The cytoplasmic domain of CALML5 contains a number of hypothetical protein-coding regions and is known to be involved in the regulation of cellular processes such as cell adhesion and migration.

CALML5 is widely expressed in a variety of tissues, including the brain, and is highly expressed in regions of the brain that are involved in the formation of new memories and the regulation of emotional behavior. It is also expressed in other tissues, including muscle and pancreas, and has been implicated in a wide range of physiological processes, including the regulation of pain, anxiety, and depression.

One of the key functions of CALML5 is its role in synaptic plasticity. Synaptic plasticity is the ability of the brain to learn and adapt over time, and is critical for the formation of new memories, learning, and problem-solving. The regulation of synaptic plasticity is critical for the development and maintenance of normal cognitive function, and is associated with a wide range of cognitive functions, including attention, memory, and learning.

CALML5 is involved in the regulation of synaptic plasticity through its ability to modulate the activity of other proteins that are involved in the formation of new memories. For example, studies have shown that CALML5 can interact with the proteinCREB, which is involved in the regulation of DNA replication and gene expression. These interactions may help to ensure that the brain is able to effectively store and recall new memories.

In addition to its role in synaptic plasticity, CALML5 is also involved in the regulation of a variety of other physiological processes. For example, it has been shown to be involved in the regulation of pain, anxiety, and depression, and has been implicated in the development of a variety of neurological and psychiatric disorders.

Given its involvement in so many important physiological processes, it is not surprising that CALML5 is a drug target (or biomarker) of great interest. Researchers are actively searching for small molecules that can modulate the activity of CALML5 and improve its function in the treatment of a wide range of disorders. Some studies have shown that small molecules such as rapamycin and curcumin can effectively modulate the activity of CALML5, and have the potential to be used as drugs for the treatment of a variety of neurological and psychiatric disorders.

In conclusion, CALML5 is a protein that is expressed in the brain and plays a crucial role in the development and maintenance of synaptic plasticity, which is the ability of the brain to learn and adapt over time. Its involvement in the regulation of synaptic plasticity makes it a potential drug target (or biomarker) of great interest, and the study of its function and regulation is an active area of research in the fields of neuroscience and pharmacology. Further research is needed to fully understand the role of

Protein Name: Calmodulin Like 5

Functions: Binds calcium. May be involved in terminal differentiation of keratinocytes

The "CALML5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CALML5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets