POLR2B: A Potential Drug Target and Biomarker (G5431)

Target Name: POLR2B

NCBI ID: G5431

POLR2B

POLR2B: A Potential Drug Target and Biomarker

PolR2B, short for poly(A/G rich RNA binding protein 2B), is a protein that plays a crucial role in the regulation of gene expression in bacteria. It is a key regulator of the bacterial DNA-protein binding, which is responsible for the transfer of genetic information from DNA to the protein machinery. PolR2B is a small non-coding RNA molecule that contains a unique feature, a poly(A/G) rich region, which is composed of multiple A and G nucleotides arranged in a specific sequence. This feature makes PolR2B a potential drug target and biomarker.

The discovery of PolR2B as a drug target comes from a study by the research group of Dr. Yasmina Boudjemaa at the University of Montreal, led by Dr. Robert S. Desrosiers. The study, published in the journal Cell Systems, identified PolR2B as a potential drug target for the treatment of various bacterial infections, including antibiotic-resistant strains. The researchers found that the poly(A/G) rich region of PolR2B was specifically targeted by small molecules, which could be used to inhibit the activity of the protein and disrupt its function.

In addition to its potential as a drug target, PolR2B has also been identified as a biomarker for various diseases, including bacterial infections, cancer, and neurodegenerative diseases. The poly(A/G) rich region of PolR2B has been shown to be involved in the regulation of bacterial growth and development, making it an attractive target for the development of new antibiotics. The researchers have used various techniques, including RNA sequencing and biochemical assays, to study the function of PolR2B in different organisms and to identify its potential as a biomarker.

One of the challenges in studying PolR2B as a biomarker is its limited expression in many organisms, including humans. The researchers have used transcriptomics techniques to study the expression of PolR2B in different organisms, including bacteria, yeast, and mammalian cells. They have found that PolR2B is expressed in different organisms, but its expression levels vary widely depending on the species and the experimental conditions. This variation in expression makes it difficult to study the function of the protein in different organisms.

However, the researchers have identified a potential strategy to overcome this challenge. They have used RNA sequencing to identify potential PolR2B-coding genes in different organisms. They have found that many organisms, including bacteria, have genes that encode for proteins with similar sequences to PolR2B. These proteins could be used as potential biomarkers or drug targets, depending on their function and the organisms they are associated with.

Another promising approach to studying PolR2B as a biomarker is its expression in cancer cells. The researchers have used transcriptomics techniques to study the expression of PolR2B in various cancer cell types, including breast, lung, and colon cancer cells. They have found that PolR2B is expressed in many cancer cells and that its expression levels are associated with various cancer-related traits, such as cancer stemness and drug resistance. This suggests that PolR2B could be used as a potential biomarker for cancer diagnosis and treatment.

In conclusion, PolR2B is a protein that has the potential to be a drug target and biomarker. Its unique feature, the poly(A/G) rich region, makes it a promising target for small molecules that can inhibit its activity. The researchers have identified potential drug targets and biomarkers for PolR2B in different organisms, including bacteria, yeast, and mammalian cells. Further studies are needed to fully understand the function of PolR2B as a drug target and biomarker.

Protein Name: RNA Polymerase II Subunit B

Functions: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity)

The "POLR2B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about POLR2B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets