POLR3A: A Potential Drug Target and Biomarker (G11128)

Target Name: POLR3A

NCBI ID: G11128

POLR3A

POLR3A: A Potential Drug Target and Biomarker

PolR3A, short for poly(A)rribial RNA-binding protein 3A, is a gene that encodes a protein located in the nucleus of the human cell. The function of this protein is not well understood, but it is known to play a role in the regulation of gene expression and DNA replication. Despite the lack of specific function, the poly(A)rribial nature of the protein has led to the conclusion that it may be a drug target or biomarker.

The discovery of potential drug targets is a critical aspect of drug development, as it allows for the development of effective therapies for various diseases. The identification of a biomarker can also be a valuable tool for disease diagnosis and monitoring. In the case of POLR3A, its potential as a drug target and biomarker makes it an important topic of study.

The protein encoded by the POLR3A gene is composed of 21 amino acids and has a calculated molecular mass of 23.9 kDa. It is characterized by a poly(A)rribial structure, which is composed of a core region of amino acids that are primarily responsible for binding to DNA and a peripheral region of amino acids that are involved in the formation of an alphahelical structure. The poly(A)rribial nature of the protein is due to its unique structure, which allows it to interact with DNA in a stable manner.

One of the key functions of the POLR3A protein is its role in the regulation of gene expression. It is well known that gene expression is regulated by various factors, including DNA replication, transcription, and degradation. The POLR3A protein is involved in the regulation of these processes, as it has been shown to play a role in the binding of DNA to the nuclear matrix. This interaction between the protein and DNA allows it to regulate gene expression at the level of the cell.

Another function of the POLR3A protein is its role in DNA replication. DNA replication is a critical process that occurs in the cell, and it is necessary for the continuation of genetic information. The POLR3A protein is involved in the regulation of DNA replication, as it has been shown to play a role in the binding of the enzyme DNA polymerase. This interaction between the protein and the enzyme allows it to regulate the rate of DNA replication and ensure the accuracy of the genetic information.

The poly(A)rribial nature of the POLR3A protein also suggests that it may be a potential drug target. The protein's unique structure and its involvement in critical processes such as gene expression and DNA replication make it an attractive target for drug development. The use of small molecules or antibodies to interact with the protein and regulate its activity could lead to the development of new treatments for various diseases.

In conclusion, the poly(A)rribial nature of the POLR3A protein makes it an attractive candidate for drug development as a potential drug target and biomarker. Further research is needed to fully understand the function of this protein and its potential as a drug. The identification of new treatments for various diseases could have a significant impact on human health.

Protein Name: RNA Polymerase III Subunit A

Functions: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway

The "POLR3A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about POLR3A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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