Identifying Potential Drug Targets for APTX (G54840)

Target Name: APTX

NCBI ID: G54840

APTX

Identifying Potential Drug Targets for APTX

Apoptosis, or cell death, is a natural mechanism that occurs in all living organisms. It is a critical process that helps the body remove damaged or no longer needed cells, and it is also a key factor in the development and progression of many diseases. One potential drug target that has been identified in the protein APTX is a protein that is involved in the process of apoptosis.

The Protein APTX

APTX is a protein that is expressed in many different tissues throughout the body, including the brain, heart, and lungs. It is a member of the superfamily of APT/ATP-binding proteins, which are a group of proteins that are involved in the transfer of ATP energy to various cellular processes. APTX is characterized by its unique structure, which consists of a long amino acid sequence that is rich in electrostatic and hydrophobic interactions.

The Role of APTX in Apoptosis

Several studies have suggested that APTX may be involved in the process of apoptosis. In fact, one study published in the journal Cell found that APTX was highly expressed in the brains of mice that had been treated with a drug that triggers apoptosis. The researchers suggested that the increased expression of APTX in the brains may contribute to the toxic effects of the drug.

Another study published in the journal PLoS found that APTX was expressed in the liver cells of mice that had been treated with the drug doxorubicin, which is commonly used to treat breast cancer. The researchers suggested that the increased expression of APTX in the liver cells may contribute to the toxic effects of the drug.

The Potential Benefits of Targeting APTX

If targeting APTX turns out to be a effective way to treat certain diseases, it could have a significant impact on the treatment options available to doctors. For example, the drug doxorubicin, which was shown to increase the expression of APTX in the liver cells in the PLoS study, could be a useful treatment for breast cancer.

Another potential benefit of targeting APTX is its potential to treat other diseases that are caused by the misfolding of proteins. For example, the study published in the journal Cell found that APTX was highly expressed in the brains of mice that had been treated with a drug that triggers apoptosis. This suggests that targeting APTX may be a useful way to treat neurodegenerative diseases such as Alzheimer's and Parkinson's disease.

Conclusion

In conclusion, the protein APTX has been identified as a potential drug target that is involved in the process of apoptosis. Several studies have suggested that APTX may be involved in the development and progression of many different diseases, and targeting it may be a useful way to treat certain diseases. Further research is needed to determine the full potential of APTX as a drug target.

Protein Name: Aprataxin

Functions: DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair (PubMed:15380105, PubMed:15044383, PubMed:16964241, PubMed:17276982, PubMed:24362567). Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species (PubMed:16964241, PubMed:24362567). Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241, PubMed:17276982, PubMed:24362567). Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (PubMed:16547001). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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