Target Name: DPEP3
NCBI ID: G64180
Review Report on DPEP3 Target / Biomarker Content of Review Report on DPEP3 Target / Biomarker
DPEP3
Other Name(s): dipeptidase 3 | Dipeptidase 3 (isoform a) | testis secretory sperm-binding protein Li 211a | DPEP3 variant 1 | DPEP3_HUMAN | membrane-bound dipeptidase 3 | Metallopeptidase (family M19) | metallopeptidase (family M19) | Membrane-bound dipeptidase 3 | Dipeptidase 3 | MBD3 | Dipeptidase 3, transcript variant 1

Dipeptidase 3: Potential Drug Target and Biomarker

Dipeptidase 3 (DPEP3) is a protein that is expressed in various tissues throughout the body, including the brain, pancreas, and heart. It is a member of the superfamily of dipeptidases, which are a group of enzymes that cleave peptides that contain two amino acids acids at each carbon atom. One of the unique features of DPEP3 is its specificity for the peptide sequence composed of alanine and glutamic acid, which is often referred to as the \"Beef 'end\" sequence.

DPEP3 is involved in a wide range of physiological processes in the body, including the regulation of protein synthesis and degradation, cell signaling, and inflammation. It is also involved in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

DPEP3 has also been identified as a potential drug target in several studies. Its involvement in the regulation of protein synthesis and degradation makes it a potential target for small molecules that can modulate its activity. Additionally, its role in cell signaling and inflammation makes it a potential target for drugs that can modulate its expression or activity.

One of the most promising potential drug targets for DPEP3 is the inhibition of its activity by small molecules that can modulate its stability or activity. This can be achieved through a variety of methods, including inhibition of the activity of DPEP3 itself or its substrate, inhibition of the enzymes that regulate its activity, or inhibition of the pathways that are affected by its activity.

Another approach to targeting DPEP3 is the use of small molecules that can modulate its expression or activity. This can be achieved through a variety of methods, including the use of drugs that can bind to specific interacting regions of the protein, the use of drugs that can modify its stability or activity, or the use of drugs that can affect the interactions of its components.

DPEP3 is also a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its expression is often increased in these diseases, and its activity is often modified in ways that are associated with the progression of these diseases. The use of DPEP3 as a biomarker for these diseases has the potential to provide valuable information for the development of new treatments.

In conclusion, Dipeptidase 3 (DPEP3) is a protein that is involved in a wide range of physiological processes in the body. Its specificity for the Beef 'end\" sequence makes it a potential target for small molecules that can modulate its activity. Additionally , its involvement in the regulation of protein synthesis and degradation, cell signaling, and inflammation makes it a potential target for drugs that can modulate its expression or activity. Its potential as a drug target and biomarker make it an attractive target for future research.

Protein Name: Dipeptidase 3

Functions: Lacks dipeptidase activity and is unable to hydrolyze cystinyl-bis-glycine, leukotriene D4 and the beta-lactam antibiotic imipenem (PubMed:32325220). The absence of activity may be due to the inability of asparagine (instead of aspartate found in DPEP1/2) at position 359 to function as the acid/base catalyst and activate the nucleophilic water/hydroxide (PubMed:32325220). A tyrosine (instead of histidine) at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance (PubMed:32325220)

The "DPEP3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DPEP3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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