PPP2CB: A Potential Drug Target and Biomarker (G5516)

Target Name: PPP2CB

NCBI ID: G5516

PPP2CB

PPP2CB: A Potential Drug Target and Biomarker

PPP2CB: A Potential Drug Target and Biomarker for Serine/Threonine-Protein Phosphatase 2A Catalytic Subunit Beta Isoform

Serine/threonine-protein phosphatase 2A (PPPA2A) is a key enzyme in the regulation of protein phosphorylation, which is a critical process involved in cell signaling, protein folding, and survival. The PPP2A enzyme has four isoforms, A, B, C, and D, each with distinct catalytic properties and functions. The catalytic subunit (C) of PPP2A is the most abundant isoform, and it plays a crucial role in the regulation of cellular processes, including cell signaling, DNA replication, and metabolism. However, the full extent of its functions and potential as a drug target are not well understood.

PPP2CB: A Potential Drug Target

The catalytic subunit (C) of PPP2A is a 21-kDa protein that contains a distinct N-terminal region, a catalytic domain, and a C-terminal region. The catalytic domain is the site of the enzyme's catalytic activity and is responsible for the catalytic conversion of ATP to ADP, resulting in the removal of phosphate groups from target proteins. The C subunit has distinct subcellular localization patterns, with the N-terminal region being predominantly nuclear, the catalytic domain predominantly cytoplasmic, and the C-terminal region predominantly cytoplasmic.

Several studies have suggested that the catalytic subunit of PPP2A may be a potential drug target due to its unique catalytic properties and the involvement of several diseases, including cancer, neurodegenerative diseases, and metabolic disorders. The PPP2A enzyme has been implicated in various cellular processes, including cell signaling, DNA replication, apoptosis, and autophagy. Therefore, targeting the catalytic subunit of PPP2A may provide new insights into the regulation of these processes and may reveal new therapeutic opportunities.

PPP2CB as a Biomarker

The catalytic subunit (C) of PPP2A has also been suggested as a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and metabolic disorders. The PPP2A enzyme has been shown to be involved in various cellular processes, including cell signaling, DNA replication, apoptosis, and autophagy. Therefore, targeting the catalytic subunit of PPP2A may provide new insights into the regulation of these processes and may reveal new therapeutic opportunities.

PPP2CB as a Potential Drug Target

The catalytic subunit (C) of PPP2A has distinct catalytic properties that make it a potential drug target. The C subunit has a unique catalytic mechanism that involves the conversion of ATP to ADP, resulting in the removal of phosphate groups from target proteins. This mechanism allows the C subunit to selectively target specific phosphorylated proteins and to regulate their activity. Therefore, targeting the C subunit of PPP2A may provide new insights into the regulation of cellular processes and may reveal new therapeutic opportunities.

Conclusion

The catalytic subunit (C) of PPP2A is a key enzyme in the regulation of protein phosphorylation, which is a critical process involved in cell signaling, protein folding, and survival. The C subunit has distinct subcellular localization patterns and is involved in various cellular processes, including cell signaling, DNA replication, apoptosis, and autophagy. Therefore, targeting the C subunit of PPP2A may provide new insights into the regulation of these processes and may reveal new therapeutic opportunities. As a potential drug target and biomarker, the C subunit of PPP2A may be a valuable target for the development of new therapeutic strategies for various diseases, including cancer, neurodegenerative diseases, and metabolic disorders.

Protein Name: Protein Phosphatase 2 Catalytic Subunit Beta

Functions: Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase

The "PPP2CB Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PPP2CB comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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