ASTN1: A Potential Drug Target for Various Diseases (G460)

Target Name: ASTN1

NCBI ID: G460

ASTN1

ASTN1: A Potential Drug Target for Various Diseases

Astrotactin-1 (ASTN1) is a protein that is expressed in various tissues of the body, including the brain, heart, kidneys, and liver. It is a member of the actinin family, which is known for their role in cell signaling and cytoskeletal organization. While ASTN1 has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases, more research is needed to fully understand its function and potential applications.

The actinin family is characterized by the presence of a unique heparan sulfate unit (HAS) in the protein sequence. This unit is known for its ability to interact with various signaling molecules, including tyrosines and actins. In addition to its role in cell signaling, ASTN1 has also been shown to play a role in the regulation of cytoskeletal organization and the assembly of axonal tracts in the nervous system.

One of the unique features of ASTN1 is its ability to interact with the protein Fyn. Fyn is a protein that is involved in the regulation of cell signaling, including the signaling pathways that are responsible for the development and progression of cancer. By interacting with Fyn, ASTN1 has been shown to play a role in the regulation of cellular signaling, including the inhibition of cell proliferation and the regulation of cell death.

In addition to its role in cell signaling, ASTN1 has also been shown to have potential as a drug target. Several studies have shown that ASTN1 can be targeted by small molecules, including inhibitors of tyrosine kinase activity. These inhibitors have been shown to inhibit the activity of ASTN1 and to reduce the production of Fyn, suggesting that ASTN1 may be a useful target for the treatment of diseases that are characterized by the overproduction or dysfunction of signaling molecules.

Another potential application of ASTN1 as a drug target is its role in the regulation of cytoskeletal organization and the assembly of axonal tracts in the nervous system. ASTN1 has been shown to play a role in the regulation of the cytoskeleton, including the maintenance of a normal size and structure of the microtubules that make up the axonal tracts in the nervous system. This is important for the proper functioning of the nervous system, as axonal tracts are responsible for the transport of signals from the brain to the rest of the body.

In addition to its role in the regulation of cytoskeletal organization, ASTN1 has also been shown to play a role in the development and progression of neurodegenerative disorders. Several studies have shown that ASTN1 is involved in the regulation of the production of neurodegenerate proteins, including beta-amyloid peptides, which are thought to contribute to the development of Alzheimer's disease. In addition, ASTN1 has also been shown to play a role in the regulation of the translation of genes into the cell membrane, which is important for the production of the neurotransmitters that are responsible for the regulation of brain function.

In conclusion, ASTN1 is a protein that has been identified as a potential drug target and biomarker for a variety of diseases. Its unique role in the regulation of cell signaling and cytoskeletal organization, as well as its involvement in the regulation of neurodegenerative disorders, make it an attractive target for further research and development. While more research is needed to fully understand the function of ASTN1 and its potential applications, its potential as a drug target and biomarker is an exciting area of study that could have significant implications for the treatment of a variety of diseases.

Protein Name: Astrotactin 1

Functions: Neuronal adhesion molecule that is required for normal migration of young postmitotic neuroblasts along glial fibers, especially in the cerebellum. Required for normal rate of migration of granule cells during brain development and for normal cerebellum development

The "ASTN1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ASTN1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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