Discovering the Potential Drug Target ATG14: Beclin 1-Associated Autophagy-Related Key Regulator

Target Name: ATG14

NCBI ID: G22863

ATG14

Discovering the Potential Drug Target ATG14: Beclin 1-Associated Autophagy-Related Key Regulator

Autophagy, the process of self-cleaning by the body's cells, is a crucial aspect of cellular metabolism and has been linked to various diseases, including cancer, neurodegenerative disorders, and metabolic diseases. The regulation of autophagy is critical for maintaining cellular homeostasis and has the potential to be a therapeutic target in diseases with unmet needs. One of the key regulators of autophagy is ATG14, also known as Beclin 1-associated autophagy-related key regulator (BA-APRKR), which is a protein that plays a crucial role in the regulation of autophagy at the cellular level.

In this article, we will explore the life cycle, structure, and function of ATG14, as well as its potential as a drug target and biomarker.

Life Cycle and Structure

ATG14 is a 22 kDa protein that is expressed in various tissues, including skeletal muscles, heart, brain, and organs. The protein has a molecular weight of 40 kDa and consists of a N-terminal cytoplasmic domain, a transmembrane segment, and a C-terminal T-cell antigen (TCR) domain. The TCR domain is a glycoprotein-like structure that is involved in cell-cell interaction and signaling.

ATG14 is associated with the endoplasmic reticulum (ER) and has been shown to be involved in the regulation of autophagy. The ER is a protein that retrieves and transports proteins from the cytoplasm to the

Protein Name: Autophagy Related 14

Functions: Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity)

The "ATG14 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ATG14 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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