M12 Family of Enzymes: Potential Drug Targets Or Biomarkers (G431705)

Target Name: ASTL

NCBI ID: G431705

ASTL

M12 Family of Enzymes: Potential Drug Targets Or Biomarkers

Astacin-like metalloendopeptidase (M12) is a protein that belongs to the M12 family of enzymes, which are involved in the detoxification of xenobiotics and other harmful substances in the body. This protein has been identified as a potential drug target or biomarker due to its unique structure and its ability to interact with certain drugs.

The M12 family of enzymes consists of a variety of different proteins, including Astacin, which is also known as N-acetylastacin, and M1, M2, and M3, which are also known as 尾-glucuronidase, 纬-glucuronidase, and 未-glucuronidase, respectively. These enzymes are found in various organisms, including bacteria, archaea, and eukaryotes.

One of the key features of the M12 family of enzymes is their ability to catalyze the detoxification of xenobiotics, such as drugs, pesticides, and other harmful substances. This is accomplished through the use of a unique active site, which allows the enzymes to bind to and activate these substances.

The M12 family of enzymes also have a unique structure that is composed of multiple domains, including an N-terminus, a catalytic core, and a C-terminus. The N-terminus is responsible for introducing the enzyme to its substrate, while the catalytic core is the active site where the substrate is transformed into its active form. The C-terminus is responsible for the stability and localization of the enzyme in the cell.

One of the unique aspects of the M12 family of enzymes is their ability to interact with certain drugs. For example, several studies have shown that the M1 enzyme can interact with the drug metformin, which is used to treat type 2 diabetes. This interaction occurs through the use of a unique conformational change that allows the enzyme to bind to the drug more strongly.

Another potential drug target for the M12 family of enzymes is their ability to detoxify certain metabolites, such as phenylbutyrate, which is a metabolite of the drug phenylbuterol. This is accomplished through the use of the M2 enzyme, which has been shown to have a high affinity for phenylbutyrate.

In addition to its potential as a drug target, the M12 family of enzymes also has a role in the detoxification of other harmful substances in the body. For example, the M12 enzyme has been shown to be involved in the detoxification of the neurotoxin BMAA, which is a byproduct of the plant compound concinna, which can cause harm to the nervous system.

Overall, the M12 family of enzymes is a unique and important group of proteins that are involved in the detoxification of xenobiotics and other harmful substances in the body. Their ability to interact with certain drugs and their role in the detoxification of certain metabolites make them potential drug targets or biomarkers. Further research is needed to fully understand the unique mechanisms of the M12 family of enzymes and to develop new treatments for a variety of diseases.

Protein Name: Astacin Like Metalloendopeptidase

Functions: Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding

The "ASTL Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ASTL comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets