ATF6: A Protein Regulator of Cell Homeostasis and Potential Drug Target

Target Name: ATF6

NCBI ID: G22926

ATF6

ATF6: A Protein Regulator of Cell Homeostasis and Potential Drug Target

ATF6 (ATF6A_HUMAN) is a protein that is expressed in various tissues throughout the body, including muscle, bone, and organs. It is a key regulator of the homeostasis of cells, and is involved in a wide range of cellular processes, including cell signaling, DNA replication, and stress response.

ATF6 has also been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The protein encoded by the ATF6 gene is a 21-kDa protein that consists of 194 amino acid residues. It has a molecular weight of 21.1 kDa and a calculated pI of 4.9. ATF6 is highly expressed in various tissues, including muscle, bone, heart, and brain. It is also expressed in the placenta and testes, and has been shown to be highly expressed in cancer tissues.

ATF6 is involved in a wide range of cellular processes that are essential for maintaining cellular homeostasis. It is a key regulator of cell signaling, and is involved in the regulation of cell proliferation, differentiation, and stress response. It is also involved in the regulation of DNA replication and repair, and is a transcription factor that can promote the expression of various genes.

In addition to its role in cellular signaling, ATF6 is also recognized as a potential drug target and biomarker for various diseases. For example, ATF6 has been shown to be involved in the development and progression of cancer, and is a potential target for cancer therapies. It is also recognized as a potential biomarker for neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

ATF6 is also a potential target for autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. It is involved in the regulation of immune cell function, and is a potential target for the development of autoimmune disorders.

In conclusion, ATF6 is a protein that is expressed in various tissues throughout the body and is involved in a wide range of cellular processes that are essential for maintaining cellular homeostasis. It is also recognized as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Further research is needed to fully understand the role of ATF6 in these diseases and to develop effective therapies.

Protein Name: Activating Transcription Factor 6

Functions: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane (PubMed:10564271, PubMed:11158310, PubMed:11779464). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:10564271, PubMed:11158310, PubMed:11779464)

The "ATF6 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ATF6 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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