The Potential Drug Target and Biomarker ATAD2 (ATAD2_HUMAN) (G29028)

Target Name: ATAD2

NCBI ID: G29028

ATAD2

Other Name(s): ATAD2_HUMAN | PRO2000 | L16 | ATPase family AAA domain containing 2 | MGC142216 | ATPase family AAA domain-containing protein 2 | MGC29843 | AAA nuclear coregulator cancer-associated protein | MGC131938 | MGC5254 | DKFZp667N1320 | CT137 | ANCCA

The Potential Drug Target and Biomarker ATAD2 (ATAD2_HUMAN)

Introduction

ATAD2 (ATAD2_HUMAN) is a protein that is expressed in various tissues of the human body, including the brain, heart, and skeletal muscles. It is a key regulator of the antioxidant response and has been implicated in a wide range of physiological processes, including muscle growth and repair, inflammation, and cellular stress. In recent years, researchers have increasingly recognized the potential of ATAD2 as a drug target and biomarker. In this article, we will explore the biology of ATAD2 and its potential as a drug target, as well as the research being done to develop ATAD2-based diagnostics and therapies.

The Biology of ATAD2

ATAD2 is a member of the ATAD family of proteins, which are involved in the regulation of antioxidant responses in various organisms. The ATAD family consists of four subunits: ATAD1, ATAD2, ATAD3, and ATAD4. These subunits share a conserved catalytic core and a common framework that includes a nucleotide-binding domain, a hypervariable region (HVR), and a C-terminal region that is involved in protein-protein interactions.

ATAD2 is a 22-kDa protein that is expressed in a variety of tissues, including the brain, heart, and skeletal muscles. It is highly conserved, with only a single amino acid difference between the human and mouse ATAD2 proteins. ATAD2 is involved in the regulation of cellular stress responses, including the production of reactive oxygen species (ROS) and the detoxification of ROS.

In addition to its role in cellular stress responses, ATAD2 is also involved in the regulation of cellular growth and repair. It has been shown to play a role in the regulation of muscle growth and repair, and is involved in the development of muscle fibers. ATAD2 has also been shown to be involved in the regulation of cellular apoptosis, which is a critical mechanism for tissue homeostasis and repair.

Potential Drug Target

ATAD2 has been identified as a potential drug target due to its involvement in a wide range of physiological processes. Its role in the regulation of cellular stress responses and its involvement in the regulation of cellular growth and repair make it an attractive target for small molecules that can modulate its activity. In addition, its high conservation and expression across various tissues make it a promising candidate for a drug that can be used to treat a wide range of diseases.

At present, some studies have explored the prospects of ATAD2 as a drug target. For example, a company called "ATAD2 Therapeutics" is developing a drug called "ATAD2 inhibitor", which is designed to reduce cell edema and muscle damage by inhibiting the activity of ATAD2. In addition, some studies have explored ATAD2 as a potential drug target for treating diseases such as Alzheimer's disease.

Biomarker

ATAD2 can also be used as a potential biomarker for disease diagnosis and treatment. Because ATAD2 plays an important role in a variety of physiological processes, it may become a useful biomarker. For example, some studies have explored the use of ATAD2 as a biomarker for muscle injury and disease diagnosis.

Conclusion

ATAD2 is a protein that is expressed in various tissues of the human body and is involved in a wide range of physiological processes. Its potential as a drug target and biomarker has been recognized by researchers, and various studies are being conducted to develop ATAD2-based therapies and diagnostics. As research continues to advance, the potential of ATAD2 as a drug target and biomarker will be further explored.

Protein Name: ATPase Family AAA Domain Containing 2

Functions: May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells

The "ATAD2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ATAD2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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