The Potential Drug Target or Biomarker Ass1p9 (Argininosuccinate Synthetase 1 Pseudogene 9)

Target Name: ASS1P9

NCBI ID: G454

ASS1P9

Other Name(s): Argininosuccinate synthetase 1 pseudogene 9 | ASSP9 | argininosuccinate synthetase 1 pseudogene 9

The Potential Drug Target or Biomarker Ass1p9 (Argininosuccinate Synthetase 1 Pseudogene 9)

Introduction

Ass1p9 (Argininosuccinate Synthetase 1 Pseudogene 9) is a gene that encodes a protein involved in the biosynthesis of arginine, a crucial amino acid for the growth, development, and survival of all living organisms. The failure to synthesize arginine correctly can result in a range of physiological and pathological consequences, including impaired immune response, neurodegeneration, and even death. Therefore, the regulation of arginine synthesis is a promising target for the development of new drugs with diverse therapeutic effects.

Recent studies have identified significant potential for Ass1p9 as a drug target or biomarker. The aim of this article is to provide a comprehensive overview of Ass1p9, including its function, the potential drug targets it may hold, and the current research efforts in this field.

Function and Structure of Ass1p9

The Ass1p9 gene encodes a protein with a molecular weight of approximately 43 kDa. The protein is composed of 254 amino acids, including a 21- amino acid signal peptide and a 233- amino acid catalytic domain. The catalytic domain contains a single catalytic active site , which is responsible for the substrate binding and catalytic activity of the protein.

The protein functions as a key enzyme in the biosynthesis of arginine from tryptophan, a key precursor amino acid. Arginine is a small molecule that plays a crucial role in various physiological processes, including cell signaling, inflammation, and innate immune responses. The synthesis of arginine from tryptophan is a highly regulated process, and Ass1p9 is involved in the rate limiting step of this process.

Potential Drug Targets

Ass1p9 has been identified as a potential drug target due to its involvement in the biosynthesis of arginine, which is a crucial amino acid for the growth, development, and survival of all living organisms. The failure to synthesize arginine correctly can result in a range of physiological and pathological consequences, including impaired immune response, neurodegeneration, and even death. Therefore, targeting Ass1p9 may be a promising strategy for the development of new drugs with diverse therapeutic effects.

One of the potential drug targets for Ass1p9 is the inhibition of its catalytic activity, which could lead to the inhibition of arginine biosynthesis. Several studies have shown that inhibitors of Ass1p9 can significantly reduce the levels of arginine in various cell types, including bacteria, yeast , and mammalian cells. The ability of these inhibitors to reduce arginine levels suggests that Ass1p9 may be an attractive target for the development of anti-inflammatory, neuroprotective, or anti-cancer drugs.

Another potential drug target for Ass1p9 is the modulation of its expression level. Several studies have shown that the expression level of Ass1p9 can be regulated by various factors, including growth conditions, nutrient availability, and stress levels. The ability to modulate the expression level of Ass1p9 suggests that this gene may be an attractive target for the development of drugs that can modulate cellular processes, including cell growth, apoptosis, and inflammation.

Biomarker Potential

The regulation of arginine synthesis is a critical process for the growth, development, and survival of all living organisms. Therefore, the levels of arginine in various cell types, including bacteria, yeast, and mammalian cells, can be used as biomarkers to assess the function of Ass1p9.

Studies have shown that the levels of arginine in various cell types can be affected by various conditions, including changes in nutrient availability, growth conditions, and stress levels. For example, arginine levels in bacteria have been shown to be affected by changes in growth conditions , such as changes in pH or temperature. Similarly, changes in nutrient availability, such as changes in the concentration of amino acids, have been shown to affect arginine levels in yeast.

The potential use of Ass1p9 as a biomarker for the regulation of arginine synthesis has implications for the development of new diagnostic tools and therapeutic approaches. For example, changes in arginine levels in various cell types could be used as a diagnostic marker for various diseases, including neurodegenerative diseases, cancer, and inflammatory diseases.

Current Research Efforts

Several research efforts are underway to better understand the function of Ass1p9 and to identify potential drug targets or biomarkers. These efforts include the following:

1. Isolation and characterization of Ass1p9-expressing cells and cell lines: To better understand the function of Ass1p9, researchers are working to isolate and characterize Ass1p9-expressing cells and cell lines. This will provide valuable information about the regulation of arginine synthesis by Ass1p9 and the potential impact of Ass1p9 inhibitors on cellular processes.
2. The identification of potential drug targets: Researchers are working to identify potential drug targets for Ass1p9, including inhibition of its catalytic activity and modulation of its expression level. This will provide valuable insights into the mechanisms underlying the regulation of arginine synthesis by Ass1p9 and the potential therapeutic effects of Ass1p9 inhibitors.
3. The development of Ass1p9 inhibitors: Researchers are working to synthesize and test Ass1p9 inhibitors to determine their effectiveness in modulating arginine synthesis and the potential therapeutic effects of these inhibitors.
4. The characterization of the impact of Ass1p9 inhibitors on cellular processes: Researchers are working to characterize

Protein Name: Argininosuccinate Synthetase 1 Pseudogene 9

The "ASS1P9 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ASS1P9 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets