TRPV5: Pain, Inflammation and Temperature Regulator, Potential Drug Target Or Biomarker

Target Name: TRPV5

NCBI ID: G56302

TRPV5

TRPV5: Pain, Inflammation and Temperature Regulator, Potential Drug Target Or Biomarker

TRPV5 (Transient receptor potential cation channel subfamily V subfamily 5) is a protein that is expressed in various tissues throughout the body, including the skin, hair, and nervous system. It is a type of ion channel that plays a crucial role in the regulation of pain, inflammation, and body temperature.

Recent studies have suggested that TRPV5 may be a drug target or biomarker for various diseases, including pain, cancer, and neurodegenerative disorders. This is due to the fact that TRPV5 is involved in the transmission of pain signals from the body's tissues to the central nervous system.

The TRPV5 channel is composed of four subunits: TRPV5, TRPV6, TRPV7, and TRPV8. These subunits are held together by ionic bonds, and they are responsible for the channel's conductivity. When the channel is activated, it allows calcium ions to enter the cell, which can cause a variety of downstream signaling pathways.

One of the most well-known functions of TRPV5 is its role in pain signaling. When the body experiences pain, TRPV5 is activated, allowing calcium ions to enter the cells. This increase in calcium ions can cause a variety of downstream signaling pathways, including the production of pain-related neurotransmitters, such as nitric oxide, which can contribute to the sensation of pain.

TRPV5 is also involved in the regulation of inflammation. When the body experiences inflammation, TRPV5 is activated, allowing calcium ions to enter the cells. This increase in calcium ions can cause a variety of downstream signaling pathways, including the production of pro-inflammatory cytokines, which can contribute to the inflammatory response.

In addition to its role in pain and inflammation, TRPV5 is also involved in the regulation of body temperature. When the body temperature rises, TRPV5 is activated, allowing calcium ions to exit the cells. This decrease in calcium ions can help to regulate the body's thermoneutrality, which is essential for maintaining a stable body temperature.

TRPV5 has also been suggested as a potential drug target for various diseases, including cancer and neurodegenerative disorders. For example, some studies have suggested that inhibiting TRPV5 may be an effective way to treat neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. This is because TRPV5 is involved in the regulation of the neurotransmitter glutamate, which is involved in the development and progression of these disorders.

In addition, TRPV5 has also been suggested as a potential biomarker for cancer. Some studies have shown that the expression of TRPV5 is increased in various tissues of cancer, and that inhibiting TRPV5 may be an effective way to reduce the growth and metastasis of cancer cells.

Overall, TRPV5 is a protein that plays a crucial role in the regulation of pain, inflammation, and body temperature. Recent studies have suggested that TRPV5 may be a drug target or biomarker for various diseases, including cancer and neurodegenerative disorders. Further research is needed to fully understand the role of TRPV5 in these processes and to develop effective treatments.

Protein Name: Transient Receptor Potential Cation Channel Subfamily V Member 5

Functions: Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed:11549322, PubMed:18768590). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity)

The "TRPV5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRPV5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets