STIM2: A Potential Drug Target and Biomarker for Kidney Disease

Target Name: STIM2

NCBI ID: G57620

STIM2

STIM2: A Potential Drug Target and Biomarker for Kidney Disease

Kidney disease is a leading cause of morbidity and mortality worldwide, affecting millions of individuals worldwide. Chronic kidney diseases (CKD) are the most common form of kidney disease and are characterized by a decline in kidney function over time. The development of CKD is a result of a combination of genetic and environmental factors, leading to the need for effective treatments.

STIM2, a protein that belongs to the Src tyrosine kinase family, has been identified as a potential drug target and biomarker for kidney disease. STIM2 plays a critical role in the regulation of cell survival and proliferation, and its dysfunction has been implicated in the development and progression of CKD.

The Src tyrosine kinase family is a large gene family that includes several proteins that are involved in cell signaling pathways. STIM2 is a non-catalytic protein that is expressed in a variety of tissues and cells, including the brain, heart, and kidneys. It is characterized by a unique N-terminal domain that includes a nucleotide-binding oligomerization domain (NBO), a protein-coding domain, and a C-terminal domain that is involved in protein-protein interactions.

STIM2 function

STIM2 is involved in the regulation of cell survival and proliferation by activating several signaling pathways. It plays a critical role in the development and maintenance of neural stem cells (NSCs), which are a crucial source of neural diversity and are involved in the development of various neurological disorders.

STIM2-mediated signaling pathways have been implicated in the development of several types of cancer, including neuro cancer. Studies have shown that STIM2 can promote the growth and survival of cancer cells by inhibiting the negative signaling effects of several growth factors, such as PDGF, TGF-β1, and NF-kappa-B.

In addition to its role in cancer development, STIM2 has also been implicated in the regulation of cellular stress responses, inflammation, and autophagy. It has been shown to play a critical role in the regulation of cell survival and proliferation in response to various stressors, including oxidative stress, UV radiation, and temperature.

STIM2 as a drug target

The potential use of STIM2 as a drug target is based on its involvement in several signaling pathways that are involved in the development and progression of CKD. Several studies have shown that STIM2 can be targeted with small molecules and have potential as a therapeutic intervention for CKD.

One of the potential mechanisms by which STIM2 can be targeted is its role in the regulation of cellular stress responses. CKD is often associated with chronic cellular stress, and it is thought that this stress can contribute to the development and progression of CKD.

STIM2 has been shown to play a critical role in the regulation of cellular stress responses by activating several signaling pathways. It has been shown to promote the generation of reactive oxygen species (ROS) in response to cellular stress, which can damage cellular components and contribute to the development of oxidative stress-induced diseases.

In addition to its role in cellular stress responses, STIM2 has also been shown to play a critical role in the regulation of inflammation. It has been shown to promote the recruitment of immune cells to the site of injury or damage, which can contribute to the development of inflammatory diseases.

Furthermore, STIM2 has also been shown to play a critical role in the regulation of autophagy, a process that is involved in the breaking down of damaged cellular components. The dysfunction of autophagy has been implicated in the development and progression of several diseases, including cancer.

The potential use of STIM2 as a drug target is based on its involvement in several signaling pathways that are involved in the development and progression of CKD. Several studies have shown that STIM2 can be targeted with small molecules and have potential as a therapeutic intervention for CKD. Further research is needed to

Protein Name: Stromal Interaction Molecule 2

Functions: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx

The "STIM2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about STIM2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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