Regulating Sex Hormones and Body Composition (G6462)

Target Name: SHBG

NCBI ID: G6462

SHBG

Regulating Sex Hormones and Body Composition

SHBG, or Sex hormone binding globulin, is a protein that plays a critical role in regulating the levels of sex hormones in the body. It is a transmembrane protein that is expressed in various tissues throughout the body, including the brain, fat cells, and uterus.

SHBG is regulated by several hormones, including testosterone and estradiol, which are produced by the testes and ovaries, respectively. Testosterone is a key androgen that plays a crucial role in the development and maintenance of male reproductive features, while estradiol is a key estrogen that is responsible for the development and maintenance of female reproductive features.

SHBG helps to regulate the levels of these hormones in the body by binding to them and preventing them from being too active. This is done by theSHBG protein's fingers, which are regions of the protein that are responsible for binding to the androgens and estrogens.

One of the functions of SHBG is to protect the body from the negative effects of androgens and estrogens. For example, androgens can cause prostate cancer, so SHBG helps to keep the levels of androgens in check. Similarly, estrogens can cause breast cancer, so SHBG helps to keep the levels of estrogens in check.

Another function of SHBG is to regulate the production of sex hormones by the gonads. In humans, the testes produce testosterone, while the ovaries produce estradiol. SHBG helps to regulate the levels of these hormones by binding to them and preventing them from being too active.

SHBG is also involved in the regulation of body weight and composition. It helps to regulate the levels of fat in the body by binding to fat cells and preventing them from being too active. This is done by the SHBG protein's fingers, which are regions of the protein that are responsible for binding to the fat cells and preventing them from being too active.

In addition to its role in regulating the levels of sex hormones, SHBG is also involved in the regulation of bone density. It helps to regulate the levels of calcium in the body by binding to the osteoclasts, which are cells that break down bone tissue. This is done by the SHBG protein's fingers, which are regions of the protein that are responsible for binding to the osteoclasts and preventing them from being too active.

SHBG is also involved in the regulation of insulin sensitivity. It helps to regulate the levels of glucose in the body by binding to the GLUT4 cells, which are cells that are responsible for regulating blood sugar levels. This is done by the SHBG protein's fingers, which are regions of the protein that are responsible for binding to the GLUT4 cells and preventing them from being too active.

In conclusion, SHBG is a protein that plays a critical role in regulating the levels of sex hormones in the body. It is expressed in various tissues throughout the body and is regulated by several hormones, including testosterone and estradiol. SHBG helps to protect the body from the negative effects of androgens and estrogens, regulate the production of sex hormones by the gonads, regulate body weight and composition, and regulate insulin sensitivity.

Given its role in regulating the levels of sex hormones, SHBG is a potential drug target for diseases that are caused by imbalances in the levels of these hormones. For example, SHBG is often used to treat conditions that are caused by low levels of testosterone, such as androgen deficiency syndrome. This is because SHBG helps to regulate the levels of testosterone in the body and can help to restore normal levels.

In addition, SHBG is also being studied as a potential biomarker for several diseases, including cancer. This is because SHBG is often affected by changes in the levels of hormones

Protein Name: Sex Hormone Binding Globulin

Functions: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration

The "SHBG Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SHBG comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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