SMARCB1: A Potential Drug Target for Cancer and Diseases (G6598)

Target Name: SMARCB1

NCBI ID: G6598

SMARCB1

SMARCB1: A Potential Drug Target for Cancer and Diseases

SMARCB1 (SMARCs/MARCs) is a gene that encodes a protein known as SMARCB1, which is a key regulator of stem cell proliferation and differentiation. The protein encoded by SMARCB1 is involved in the regulation of several cellular processes, including cell growth, apoptosis, and transcriptional regulation.

SMARCB1 is a nuclear protein that is primarily expressed in stem cells, terminal cistern cells, and various tissues of the body. It plays a crucial role in the regulation of stem cell proliferation by preventing the cell from entering a state of apoptosis. When SMARCB1 is activated, it binds to specific DNA sequences, preventing the binding of growth factors that would otherwise induce cell growth. This is important for maintaining stem cell stemness and for the regulation of tissue homeostasis.

SMARCB1 is also involved in the regulation of cell apoptosis, which is the process by which cells undergo programmed cell death. Through its role in the regulation of apoptosis, SMARCB1 can influence the number and pattern of apoptotic cells in the body, contributing to tissue homeostasis.

In addition to its role in stem cell proliferation and apoptosis, SMARCB1 is also involved in transcriptional regulation. It has been shown to play a role in the regulation of stem cell gene expression, by binding to specific DNA sequences and modulating the activity of transcription factors . This modulation of gene expression is important for the regulation of stem cell stemness and for the development of various diseases.

SMARCB1 is a protein that has been identified as a potential drug target in several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. For example, studies have shown that SMARCB1 is overexpressed in various types of cancer, including breast, lung, and colon cancer. This overexpression is thought to contribute to the development and progression of these diseases.

Furthermore, SMARCB1 has also been shown to be involved in the regulation of the immune response, which is an important aspect of disease development and treatment. Overexpression of SMARCB1 has been observed in various autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. This overexpression is thought to contribute to the development and progression of these diseases.

SMARCB1 is also involved in the regulation of stem cell maintenance and the aging process. Through its role in stem cell proliferation and apoptosis, SMARCB1 can influence the number and quality of stem cells in the body, contributing to tissue homeostasis and the development of various diseases.

In conclusion, SMARCB1 is a gene that encodes a protein involved in several cellular processes in the body, including stem cell proliferation, apoptosis, and transcriptional regulation. It plays a crucial role in the regulation of stem cell stemness and for the development of various diseases . As a result, SMARCB1 is an attractive target for drug development in several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

Protein Name: SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1

Functions: Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1

The "SMARCB1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SMARCB1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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