TAF7: A Potential Drug Target for Cell Adhesion, Migration and Inflammation

Target Name: TAF7

NCBI ID: G6879

TAF7

TAF7: A Potential Drug Target for Cell Adhesion, Migration and Inflammation

TAF7 (TAFII55) is a protein that is expressed in various tissues throughout the body. It is a member of the TAF7 family, which includes several similar proteins that are involved in the regulation of cellular processes such as cell adhesion, migration, and invasion. TAF7 is of particular interest as a potential drug target due to its involvement in several disease processes, including cancer, neurodegenerative diseases, and autoimmune disorders.

The TAF7 protein is composed of 219 amino acid residues and has a calculated molecular mass of 33.9 kDa. It is expressed in a variety of tissues, including muscle, heart, brain, and kidney. TAF7 is involved in several cellular processes, including cell adhesion , migration, and invasion. It plays a role in the regulation of these processes by interacting with several other proteins, including FAK, N-cadherin, and vimentin.

One of the most significant functions of TAF7 is its role in cell adhesion. TAF7 is involved in the formation of tight junctions, which are a type of cell-cell adhesion that helps to maintain tissue structure and prevent the loss of cells. TAF7 has been shown to play a role in the regulation of tight junction formation by interacting with the protein E-cadherin. This interaction between TAF7 and E-cadherin allows TAF7 to regulate the formation of tight junctions and maintain the integrity of tissues.

TAF7 is also involved in the regulation of cell migration. Cell migration is a critical process that enables cells to move to new locations in the body and play a role in the development and progression of many diseases, including cancer. of cell migration by interacting with the protein alpha platelet glycoprotein (APC) and the protein N-cadherin. These interactions allow TAF7 to regulate the movement of cells and control the formation of new tissues.

TAF7 is also involved in the regulation of inflammation. Inflammation is a critical process that helps the body to respond to harmful stimuli, including damage to tissues and the formation of immune complexes. TAF7 is involved in the regulation of inflammation by interacting with the protein NF -kappa-B. This interaction between TAF7 and NF-kappa-B allows TAF7 to regulate the production of pro-inflammatory cytokines and control the recruitment of immune cells to sites of inflammation.

TAF7 is also involved in the regulation of cell survival. Cell survival is a critical process that enables cells to continue to function and divide in the face of various cellular stressors, including those that are caused by diseases such as cancer. TAF7 is involved in the regulation of cell survival by interacting with the protein p53. This interaction between TAF7 and p53 allows TAF7 to regulate the production of anti-apoptotic cytosins and control the survival of cells under stress.

TAF7 is also involved in the regulation of DNA replication. DNA replication is a critical process that enables cells to generate new copies of their genetic material in response to the replication of DNA. TAF7 is involved in the regulation of DNA replication by interacting with the protein DNA-binding domain of the enzyme RPA1. This interaction between TAF7 and RPA1 allows TAF7 to regulate the replication of DNA and ensure the accuracy of genetic information.

In conclusion, TAF7 is a protein that is involved in several critical cellular processes that are essential for the maintenance of tissue structure and the integrity of organisms. Its involvement in these processes makes TAF7 an attractive target for drug development, particularly for the treatment of diseases such as cancer, neurodegenerative diseases, and autoimmune disorders. Further research is needed to fully understand the role of TAF7 in these processes and to develop effective therapies that target this protein.

Protein Name: TATA-box Binding Protein Associated Factor 7

Functions: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473, PubMed:10438527). TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2 (PubMed:33795473). Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta) (PubMed:10438527)

The "TAF7 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TAF7 comprehensively, including but not limited to:
•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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