UBA7: A Potential Drug Target and Biomarker for Ubiquitin-Activating Enzyme E1-Related Protein

Target Name: UBA7

NCBI ID: G7318

UBA7

UBA7: A Potential Drug Target and Biomarker for Ubiquitin-Activating Enzyme E1-Related Protein

Ubiquitin (U) is a protein that plays a critical role in the regulation of protein-protein interactions, DNA replication, and post-translational modification (PTM) among others. Ubiquitin-activating enzyme E1 (UBA1) is a key enzyme that adds a ubiquitin tag to target proteins, which plays a crucial role in protein folding, localization, and degradation. The dysfunction of UBA1 has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The search for new therapeutic targets and biomarkers has led to the exploration of UBA1 and its associated proteins, including UBA7. UBA7 is a protein that is highly conserved across various species, including humans, and has been shown to have similar functions as UBA1 in regulating protein-protein interactions and DNA replication.

Potential Drug Targets

UBA7 can be potential drug targets due to its unique structure and its involvement in various cellular processes. One of the major drug targets for UBA7 is the inhibition of its activity. The inhibition of UBA7 activity can potentially lead to the collapse of the protein-protein interaction network and disrupt the regulation of protein-protein interactions, leading to the development of various diseases.

An inhibitor of UBA7 could be used to treat diseases that are characterized by the dysfunction of the protein-protein interaction network, such as cancer, neurodegenerative diseases, and autoimmune disorders. For example, inhibitors of UBA7 have been shown to be effective in treating various cancers, including breast cancer and colorectal cancer.

Another potential drug target for UBA7 is the regulation of DNA replication. UBA7 is involved in the regulation of DNA replication, and its dysfunction has been implicated in the development of various diseases, including cancer. Inhibitors of UBA7 activity could be used to treat cancer by inhibiting its ability to regulate DNA replication.

Biomarkers

UBA7 is a protein that can be used as a biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. The levels of UBA7 in various biological samples, such as tissue, blood, and urine, can be used as a diagnostic or predictive marker for diseases.

One of the major applications of UBA7 as a biomarker is its ability to be used as a diagnostic marker for cancer. UBA7 is expressed in various types of cancer, including breast cancer, lung cancer, and colorectal cancer. The levels of UBA7 in these cancer tissues can be used to diagnose the disease and to monitor the effectiveness of various treatments.

Another application of UBA7 as a biomarker is its ability to be used as a predictive marker for neurodegenerative diseases. UBA7 is involved in the regulation of protein-protein interactions and has been implicated in the development of various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. The levels of UBA7 in individuals with neurodegenerative diseases can be used to predict the severity of the disease and to identify potential therapeutic targets.

Finally, UBA7 can be used as a biomarker for autoimmune disorders. UBA7 is involved in the regulation of protein-protein interactions and has been implicated in the development of various autoimmune disorders, including rheumatoid arthritis and multiple sclerosis. The levels of UBA7 in individuals with autoimmune disorders can be used to diagnose the disease and to identify potential therapeutic targets.

Conclusion

UBA7 is a protein that plays a critical role in the regulation of protein-protein interactions and DNA replication. Its dysfunction has been implicated in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a potential drug target and biomarker, UBA7 is a promising target for the development of new therapeutic drugs for the treatment of these diseases. Further research is needed to fully understand the functions of UBA7 and to develop effective therapies based on its properties.

Protein Name: Ubiquitin Like Modifier Activating Enzyme 7

Functions: Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein

The "UBA7 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about UBA7 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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