Understanding OR10H4: A Potential Drug Target for Olfactory Disorders
Understanding OR10H4: A Potential Drug Target for Olfactory Disorders
Olfactory receptor family 10 (OR10) is a subfamily of G protein-coupled receptors (GPCRs) that play a crucial role in sensory perception, specifically smell. OR10 is composed of four different genes: OR10A, OR10B, OR10C, and OR10D. Despite their similar function, these genes have distinct differences in their molecular structure and function. In this article, we will focus on OR10H4, a member of the OR10 subfamily and a potential drug target.
OR10H4 is a small gene that encodes a protein known as the OR10H4 receptor. This receptor is a GPCR that is expressed in various tissues, including the brain, sensory neurons, and epithelial cells. OR10H4 is involved in the sense of smell, specifically the detection of volatile organic compounds (VOCs) such as odors.
OR10H4 is a transmembrane protein that consists of an extracellular portion, a transmembrane segment, and an intracellular portion. The extracellular portion of OR10H4 is made up of a long cytoplasmic tail that is involved in protein-protein interactions and is known as the N-terminus . The transmembrane segment is responsible for the formation of the channel that allows the protein to interact with its ligand. The intracellular portion contains a unique feature known as a long terminal domain (LTD) that is involved in the formation of a protein-protein interaction complex with other GPCRs.
OR10H4 is a GPCR that uses a unique type of signal transduction mechanism known as pharmacokinetic profiling. This mechanism allows the protein to detect and respond to its ligand at the level of the individual cell, rather than at the level of the entire organism. This is Achieved through the formation of a protein-protein interaction complex with other GPCRs, including OR10H1, OR10H2, OR10H3, and OR10H6. These interactions are regulated by various intracellular signaling pathways, including tyrosination and phosphorylation.
OR10H4 is a potential drug target due to its involvement in the sense of smell and its unique mechanism of signal transduction. Many drugs that are used to treat olfactory disorders, such as those used to treat Alzheimer's disease and other neurological disorders, work by modulating the activity of OR10H4. Additionally, the regulation of OR10H4 by intracellular signaling pathways makes it a promising target for the development of new therapies for various diseases.
In conclusion, OR10H4 is a member of the Olfactory receptor family 10 subfamily and is involved in the sense of smell. Its unique mechanism of signal transduction and its involvement in the regulation of intracellular signaling pathways make it a potential drug target. Further research is needed to fully understand the role of OR10H4 in disease and to develop new treatments based on its unique properties.
Protein Name: Olfactory Receptor Family 10 Subfamily H Member 4
Functions: Odorant receptor
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More Common Targets
OR10H5 | OR10J1 | OR10J2P | OR10J3 | OR10J5 | OR10K1 | OR10K2 | OR10P1 | OR10Q1 | OR10R2 | OR10S1 | OR10T2 | OR10V1 | OR10W1 | OR10X1 | OR10Z1 | OR11A1 | OR11G2 | OR11H1 | OR11H12 | OR11H13P | OR11H2 | OR11H5P | OR11H6 | OR11H7 | OR11J2P | OR11J5P | OR11K2P | OR11L1 | OR11M1P | OR12D2 | OR12D3 | OR13A1 | OR13C2 | OR13C3 | OR13C4 | OR13C5 | OR13C8 | OR13C9 | OR13D1 | OR13F1 | OR13G1 | OR13H1 | OR13J1 | OR13Z2P | OR14A16 | OR14A2 | OR14C36 | OR14I1 | OR14J1 | OR14L1P | OR1A1 | OR1A2 | OR1B1 | OR1C1 | OR1D2 | OR1D4 | OR1D5 | OR1E1 | OR1E2 | OR1E3 | OR1F1 | OR1F2P | OR1G1 | OR1I1 | OR1J1 | OR1J2 | OR1J4 | OR1K1 | OR1L1 | OR1L3 | OR1L4 | OR1L6 | OR1L8 | OR1M1 | OR1N1 | OR1N2 | OR1P1 | OR1Q1 | OR1S1 | OR1S2 | OR2A1 | OR2A1-AS1 | OR2A12 | OR2A14 | OR2A2 | OR2A20P | OR2A25 | OR2A4 | OR2A42 | OR2A7 | OR2A9P | OR2AE1 | OR2AG1 | OR2AG2 | OR2AJ1 | OR2AK2 | OR2AL1P | OR2AM1P | OR2AP1
