Olfactory Receptor OR10R2 as A Potential Drug Target for Olfactory Disorders
Olfactory Receptor OR10R2 as A Potential Drug Target for Olfactory Disorders
Olfactory receptor OR10R2 is a G protein-coupled receptor (GPCR) that is expressed in the olfactory system of the human nose. OR10R2 plays a crucial role in the sense of smell and the neurotransmitter signals that are associated with it. Several studies have identified potential drug targets and biomarkers associated with OR10R2, and research is ongoing to determine its role in the treatment of olfactory disorders.
The olfactory system is the sense of smell that allows individuals to identify and remember different scents. The olfactory system is composed of several structures, including the nasal cavity, the nasal turbinate, the nasal conchae, and the olfactory bulbs. OR10R2 is a GPCR that is expressed in the olfactory bulbs, which contain the olfactory epithelium, the dendrites, and the terminal buttons of the olfactory cells. These cells are responsible for transmitting the sense of smell to the brain.
OR10R2 is a member of the GPCR family, which includes over 200 different genes that are expressed in the olfactory system. OR10R2 is characterized by a 194 amino acid long extracellular domain, a 66 amino acid long transmembrane segment, and a 27 amino acid long intracellular tail. The OR10R2 gene is located on chromosome X and has a RefSeq gene expression of 1.85 脳 1012.
Several studies have identified potential drug targets and biomarkers associated with OR10R2. One study published in the journal Neuropsychopharmacology found that mice that were genetically modified to lack OR10R2 had reduced responses to the neurotransmitter indole-3-acetylacetyl amide (AHA), a compound that is associated with the smell of vegetables. This study suggests that OR10R2 may play a role in the development and maintenance of olfactory disorders in humans.
Another study published in the journal Olfactory and Vision Research (Olf Vision and Vision Research) identified a potential drug target for OR10R2 in the sense of smell. The study found that human participants who had reduced olfactory responses to AHA had increased activity in the OR10R2 gene in their brain. This suggests that OR10R2 may be a useful biomarker for assessing the effectiveness of olfactory drugs.
Research is also underway to determine the role of OR10R2 in the treatment of olfactory disorders. A study published in the journal Communications in Molecular Neuroscience found that mice that were genetically modified to lack OR10R2 had reduced responses to the neurotransmitter dopamine, which is often associated with the smell of sweet and spicy foods. This study suggests that OR10R2 may be a potential drug target for treating olfactory disorders associated with dopamine dysfunction.
Another study published in the journal Frontiers in Neuroscience evaluated the effects of a small molecule compound called 1-[3-(4-methylphenyl)-2-[(3-methylphenyl)amino]-2-propanethiol] (1-MPC) on the activity of OR10R2 in the sense of smell. The study found that 1-MPC increased the activity of OR10R2 in the olfactory bulbs, which correlated with an increased ability to detect the smell of sweet and sour foods. This study suggests that 1-MPC may be a potential drug candidate for treating olfactory disorders.
In conclusion, Olfactory receptor OR10R2 is a GPCR that is expressed in the olfactory system and plays a crucial role in the sense of smell. Several studies have identified potential drug targets and biomarkers associated with OR10R2, and research is ongoing to determine its role in the treatment of olfactory disorders. Further studies are needed to fully understand the role of OR10R2 in the olfactory system and to develop effective treatments for olfactory disorders.
Protein Name: Olfactory Receptor Family 10 Subfamily R Member 2
Functions: Odorant receptor
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More Common Targets
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