Cilia- and flagella-associated protein 276 (CFAP276): A Potential Drug Target and Biomarker

Target Name: CFAP276

NCBI ID: G127003

CFAP276

Cilia- and flagella-associated protein 276 (CFAP276): A Potential Drug Target and Biomarker

Introduction

Cilia and flagella are essential organelles that play a vital role in the function of epithelial cells. They are highly dynamic structures that constantly change their shape, allowing them to move and capture particles in the surrounding environment. Cilia and flagella are also involved in the transport of various molecules, including drugs, across cell membranes. The Cilia- and flagella-associated protein 276 (CFAP276) is a protein that is highly expressed in epithelial cells and is involved in the function of cilia and flagella. In this article, we will discuss the potential drug target and biomarker properties of CFAP276.

Disease-Related Role of CFAP276

CFAP276 is a member of the superfamily of cytoskeletal proteins known as the P16 family. It is highly expressed in various epithelial tissues, including the skin, gut, and respiratory tract. CFAP276 plays a critical role in the structure and function of cilia and flagella. It is involved in the regulation of cilia formation, stability, and movement.

CFAP276 is also involved in the regulation of flagella function. It plays a role in the interaction between flagella and the microtubules of the mitotic spindle. It helps to maintain the stability of the flagella and ensures their proper movement during cell division.

In addition to its role in cilia and flagella regulation, CFAP276 is also involved in the regulation of cell adhesion, migration, and invasion. It is a strong predictor of the metastatic potential of various cancers, including breast, ovarian, and colorectal cancers.

Potential Drug Target

The drug targeting of CFAP276 has the potential to treat various diseases associated with the dysfunction of cilia and flagella. One of the main targets of CFAP276 is the regulation of cancer cell growth and metastasis.

Studies have shown that CFAP276 is involved in the regulation of cell adhesion and migration. It plays a role in the formation of tight junctions, which are a type of cell-cell adhesion, and is involved in the regulation of the movement of cells along the body's longest axis (Mie's tube).

CFAP276 is also involved in the regulation of cell proliferation. It is a strong predictor of the effectiveness of various chemotherapy drugs and has been shown to be downregulated in various types of cancer.

Biomarker

CFAP276 has also been shown to be a potential biomarker for various diseases associated with the dysfunction of cilia and flagella. Its expression is highly correlated with the severity of various diseases, including cancer, respiratory tract infections, and autoimmune disorders.

CFAP276 has also been shown to be involved in the regulation of inflammation. It is involved in the regulation of the production of pro-inflammatory cytokines, such as TNF-伪, IL-1尾, and IL-6.

Conclusion

CFAP276 is a protein that is highly expressed in various epithelial tissues and is involved in the function of cilia and flagella. Its involvement in the regulation of cell adhesion, migration, and invasion makes it a potential drug target for various diseases. Its expression is also Highly correlated with the severity of various diseases, making it a potential biomarker. Further research is needed to fully understand the role of CFAP276 in disease and its potential as a drug target and biomarker.

Protein Name: Cilia And Flagella Associated Protein 276

Functions: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). May play an important role for the maintenance of myelin-axon integrity (By similarity). May affect intracellular Ca(2+) homeostasis (PubMed:31199454)

The "CFAP276 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CFAP276 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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