CERS5: Key Enzyme in Ceramide Synthesis and Cell Signaling (G91012)

Target Name: CERS5

NCBI ID: G91012

CERS5

CERS5: Key Enzyme in Ceramide Synthesis and Cell Signaling

Ceramide synthase 5 (CERS5) is a protein that is expressed in various tissues throughout the body. It is a key enzyme in the synthesis of ceramides, which are a type of lipid molecule that plays a crucial role in cellular signaling and memory. Ceramides have also been linked to various diseases, including cancer, neurodegenerative diseases, and inflammation. As a result, CERS5 has become a focus of interest in the search for new drug targets or biomarkers.

The protein encoded by the CERS5 gene is a 21-kDa glycoprotein that is expressed in various tissues, including the brain, heart, liver, and kidney. It is highly expressed in the liver, with lower levels found in the heart, brain, and muscle. CERS5 is also expressed in various cell types, including cancer cells, and has been shown to be involved in the regulation of cellular processes, including cell signaling, DNA replication, and cell growth.

One of the key functions of CERS5 is its role in the synthesis of ceramides. Ceramides are synthesized from the amino acids Lys-21 and Lys-22, which are added to a pre-existing core structure. CERS5 catalyzes the addition of the amino acids Asp-20 and Asn-21 to the ceramide core, creating a stable and hydrophobic molecule. This reaction is critical for the development and maintenance of the ceramide signaling pathway.

In addition to its role in ceramide synthesis, CERS5 has also been shown to play a role in the regulation of cellular processes that are important for overall cellular health and function. For example, CERS5 has been shown to be involved in the regulation of cell signaling, DNA replication, and cell growth. It has also been shown to play a role in the development and maintenance of various tissues, including the brain and the immune system.

The link between CERS5 and disease has led to its potential as a drug target or biomarker. Studies have shown that CERS5 is often expressed in various diseases, including cancer, neurodegenerative diseases, and inflammation. Researchers have also shown that inhibiting CERS5 activity can lead to therapeutic effects in these diseases. For example, studies have shown that inhibiting CERS5 activity can lead to a reduction in the growth of cancer cells, and that this effect is dependent on the expression level of CERS5.

In addition to its potential as a drug target or biomarker, CERS5 has also been shown to be a useful biomarker for certain diseases. For example, CERS5 has been shown to be elevated in the blood of individuals with cancer, and has been used as a biomarker for the diagnosis and monitoring of cancer. It has also been shown to be elevated in the urine of individuals with neurodegenerative diseases, and has been used as a biomarker for the diagnosis and monitoring of these diseases.

Overall, CERS5 is a protein that has important functions in various cellular processes that are critical for overall cellular health and function. Its role in the synthesis of ceramides and its involvement in the regulation of cellular processes make it a potential drug target or biomarker. Further research is needed to fully understand the functions of CERS5 and its potential as a drug or biomarker.

Protein Name: Ceramide Synthase 5

Functions: Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA)(PubMed:16951403, PubMed:18541923, PubMed:22144673, PubMed:22661289, PubMed:23530041, PubMed:26887952, PubMed:29632068, PubMed:31916624). Can use other acyl donors, but with less efficiency (By similarity). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:31916624). Plays a role in de novo ceramide synthesis and surfactant homeostasis in pulmonary epithelia (By similarity)

The "CERS5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CERS5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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