Cilia and Flagella Associated Protein 210 (CFAP210): A Potential Drug Target and Biomarker

Target Name: CFAP210

NCBI ID: G129881

CFAP210

Cilia and Flagella Associated Protein 210 (CFAP210): A Potential Drug Target and Biomarker

Cilia and flagella associated protein 210 (CFAP210) is a protein that plays a crucial role in the function of cilia and flagella, which are essential organelles found in various cell types. Cilia and flagella are responsible for moving and filtering substances out of cells, ensuring the efficient delivery of essential nutrients and waste products. CFAP210 is a 21-kDa protein that is expressed in various cell types, including epithelial, endothelial, and muscle cells.

The Importance of CFAP210 in Cellular Functions

CFAP210 functions as a key regulator of the cilia and flagella system. It is involved in the assembly and disassembly of cilia and flagella, as well as the regulation of their dynamics. This protein is vital for the proper functioning of these organelles, as any defects in their structure or function can lead to various physiological and pathological conditions.

CFAP210 is a critical regulator of the cilia, which are small, hair-like structures that line the surface of various body cells. The cilia help to filter out large particles, such as bacteria and other debris, from the body's fluids, ensuring the healthy delivery of essential nutrients and waste products. CFAP210 is known to play a crucial role in the regulation of cilia assembly and disassembly, as well as the maintenance of their stability.

CFAP210 is also involved in the regulation of flagella, which are long, thread-like structures that are found in the cytoplasm of various cell types. Flagella are responsible for the movement of cells, allowing them to move away from potential threats, such as pathogens, and towards potential sources of nutrients and oxygen. CFAP210 is essential for the proper functioning of flagella, as any defects in their structure or function can lead to the misdirection of cell movement.

CFAP210's Role in Disease

The dysfunction of CFAP210 has been implicated in various diseases, including ciliopathies and flagellopathies. Ciliopathies are a group of disorders that affect the structure and function of cilia, leading to the inability to properly filter out particles from the body's fluids. Some of the most common ciliopathies include X-linked agenesis syndrome, known as Becker muscular dystrophy, and achalasia.

Flagellopathies, on the other hand, are a group of disorders that affect the function of flagella. These disorders can result from defects in the genes that control the synthesis and assembly of flagella. Some of the most common flagellopathies include:

1. Kearns-Sayre syndrome: This is a rare disorder that is characterized by the absence of functional flagella and the presence of a chromosomal abnormality.
2. type 18 (autosomal dominant progressive milder) : This is a milder form of the X-linked agenesis syndrome that affects the cilia.
3. type 1 (autosomal dominant): This is the most common form of the flagellopathies that affects the flagella.

CFAP210 as a Drug Target

The dysfunction of CFAP210 has been targeted as a potential drug target in the treatment of various diseases. Several studies have shown that inhibiting the activity of CFAP210 can improve the function of cilia and flagella, leading to improved delivery of essential nutrients and waste products.

One of the most promising strategies for targeting CFAP210 is the use of small molecules, such as drugs that inhibit the activity of CFAP210. Studies have shown that several small molecules have the potential to inhibit the

Protein Name: Cilia And Flagella Associated Protein 210

Functions: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating

The "CFAP210 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CFAP210 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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