CERS1: A Protein involved in Cell Signaling and Disease (G10715)

Target Name: CERS1

NCBI ID: G10715

CERS1

CERS1: A Protein involved in Cell Signaling and Disease

Ceramide synthase 1 (CERS1) is a protein that plays a crucial role in the synthesis of ceramides, which are a type of lipid molecule that are involved in various cellular processes. Ceramides have been linked to a number of biological processes, including cell signaling, inflammation, and stress resistance. As a result, CERS1 has been identified as a potential drug target and biomarker for a variety of diseases.

The CERS1 gene is located on chromosome 18 and encodes a protein that is composed of 115 amino acid residues. CERS1 is primarily localized to the endoplasmic reticulum (ER) and is involved in the synthesis of ceramides from tryptophan, a key amino acid in the synthesis of ceramides. This means that CERS1 is involved in the production of the molecules that make up the cell membrane, including ceramides.

CERS1 has been shown to play a role in a number of cellular processes. For example, it has been shown to be involved in the regulation of cell signaling by controlling the levels of various signaling molecules. Additionally, CERS1 has been linked to inflammation and stress resistance. For example, studies have shown that CERS1 is involved in the production of pro-inflammatory cytokines and that it can protect cells from stress-induced cell death.

As a result of its involvement in these processes, CERS1 has been identified as a potential drug target for a variety of diseases. For example, studies have shown that inhibiting CERS1 activity can be effective in treating a variety of conditions, including cancer, neurodegenerative diseases, and autoimmune disorders. Additionally, CERS1 has been shown to be involved in the development of certain diseases, such as heart disease and diabetes.

In addition to its potential as a drug target, CERS1 has also been identified as a potential biomarker for a variety of diseases. For example, studies have shown that levels of CERS1 have been elevated in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Additionally, CERS1 has been shown to be involved in the regulation of cellular processes that are involved in disease development, such as inflammation and stress resistance.

Overall, CERS1 is a protein that has been shown to play a crucial role in a variety of cellular processes. As a result, it has been identified as a potential drug target and biomarker for a variety of diseases. Further research is needed to fully understand the role of CERS1 in these processes and to develop effective treatments for the various diseases that are associated with its involvement.

Protein Name: Ceramide Synthase 1

Functions: Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward stearoyl-CoA (octadecanoyl-CoA; C18:0-CoA) (PubMed:17977534, PubMed:23530041, PubMed:26887952, PubMed:31916624). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:17977534, PubMed:23530041, PubMed:26887952, PubMed:31916624, PubMed:24782409). Plays a predominant role in skeletal muscle in regulating C18 ceramide and dihydroceramide levels with an impact on whole-body glucose metabolism and insulin sensitivity. Protects from diet-induced obesity by suppressing the uptake of glucose in multiple organs in a FGF21-dependent way (By similarity). Generates C18 ceramides in the brain, playing a critical role in cerebellar development and Purkinje cell function (By similarity). In response to cellular stress mediates mitophagy, a known defense mechanism against cell transformation and aging. Upon mitochondria fission, generates C18 ceramides that anchor lipidated MAP1LC3B/LC3B-II autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria (PubMed:22922758)

The "CERS1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CERS1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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