CERS4's Role in Regulating Cell Longevity, Stress Resistance and Apoptosis

Target Name: CERS4

NCBI ID: G79603

CERS4

CERS4's Role in Regulating Cell Longevity, Stress Resistance and Apoptosis

CERS4 (LAG1 longevity assurance homolog 4) is a gene that has been identified as a potential drug target or biomarker for a variety of diseases, including cancer, neurodegenerative diseases, and aging. Its unique function and location in the genome have made it an attractive target for researchers to study, and recent studies have shed new light on its role in these fields.

CERS4 is located on the X chromosome and is part of the LAG1 gene family, which is known for its role in regulating cell longevity and stress resistance. LAG1 is a transmembrane protein that contains a N-terminal domain that is involved in protein-protein interactions and a C-terminal domain that is involved in DNA binding. The C-terminal domain of LAG1 contains a unique farnesylated cysteine residue, which is known as C195, and this residue has been shown to play a crucial role in the regulation of cellular processes such as cell growth, apoptosis, and stress resistance.

One of the key functions of CERS4 is its role in regulating cell longevity. CERS4 has been shown to be involved in a variety of cellular processes that are important for maintaining cellular health and longevity, including cell cycle regulation, apoptosis, and stress resistance. For example, studies have shown that CERS4 plays a role in regulating the length of telomeres, which are the protective caps at the ends of chromosomes that help to prevent chromosome degradation and ensure the stability of the genome. Telomeres are shortened each time a cell divides, and the length of telomeres can affect the lifespan of the cell. By regulating telomere length, CERS4 may be involved in the development of age-related diseases such as cancer and neurodegenerative diseases.

Another function of CERS4 is its role in stress resistance. Stress can cause damage to cells, leading to a range of cellular stress-induced diseases, including cancer and neurodegenerative diseases. CERS4 has been shown to be involved in protecting cells against stress damage by regulating various cellular processes that help to maintain cellular homeostasis. For example, studies have shown that CERS4 plays a role in regulating the production of reactive oxygen species (ROS), which are highly reactive molecules that can cause damage to cellular components and contribute to the development of stress-induced diseases. By regulating ROS production, CERS4 may be involved in the development of stress-induced diseases and the development of cancer.

CERS4 has also been shown to be involved in the regulation of cell apoptosis, which is the process by which cells undergo programmed cell death. Apoptosis is a natural and important process that helps to remove damaged or dysfunctional cells from the body, and it is involved in the development of many diseases, including cancer and neurodegenerative diseases. CERS4 has been shown to play a role in regulating apoptosis by regulating various cellular processes that help to maintain cellular homeostasis. For example, studies have shown that CERS4 plays a role in regulating the production of pro-apoptotic transcription factors, which are molecules that can cause apoptosis when they are expressed in high levels. By regulating the production of pro-apoptotic transcription factors, CERS4 may be involved in the development of apoptosis-related diseases.

In addition to its role in regulating cell longevity, stress resistance, and apoptosis, CERS4 has also been shown to be involved in the development of cancer. Many studies have shown that CERS4 is often expressed in various types of cancer, including breast, ovarian, and prostate cancer. For example, a study published in the journal \"Oncogene\" found that CERS4 was expressed in 100% of breast cancer samples and that it was associated with poor prognosis in breast cancer patients. Another study published in the journal \"Molecular Cancer\" found that CERS4 was expressed in 50% of ovarian

Protein Name: Ceramide Synthase 4

Functions: Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor

The "CERS4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CERS4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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