GPRASP3: A Protein Involved in Cell Signaling and Neurotransmission

Target Name: GPRASP3

NCBI ID: G80823

GPRASP3

GPRASP3: A Protein Involved in Cell Signaling and Neurotransmission

GPRASP3 (P60TRP) is a protein that is expressed in various tissues throughout the body, including the brain, pancreas, and gastrointestinal tract. It is a member of the G-protein-coupled receptor (GPCR) family, which is a large superfamily of transmembrane proteins that play a critical role in cellular signaling.

GPRASP3 is a 21-kDa protein that is composed of 194 amino acid residues. It has a unique structure that consists of a catalytic alpha-helices and a carboxylic acid-containing amino acid residue. The protein has a net positive charge, which is likely due to the presence of a charged amino acid residue, such as Asp or Asn.

GPRASP3 is highly expressed in various tissues, including the brain, pancreas, and gastrointestinal tract. It is expressed in the brain at levels of 12-15% of the brain mass and in the pancreas at levels of 1-2% of the pancreatic mass . It is also expressed in other tissues, including the heart, lungs, and gastrointestinal tract.

GPRASP3 has been shown to play a critical role in several biological processes, including cell signaling, neurotransmission, and insulin sensitivity. It is involved in the regulation of several intracellular signaling pathways, including the TGF-β pathway, the Wnt pathway, and the unfolded protein response (UPR).

GPRASP3 has also been shown to be a potential drug target. Several studies have suggested that GPRASP3 may be a promising drug target for various diseases, including diabetes, obesity, and neurodegenerative diseases.

One potential mechanism by which GPRASP3 may be targeted by drugs is through its role in insulin sensitivity. Insulin sensitivity is a critical factor in the development and progression of type 2 diabetes. GPRASP3 has been shown to play a critical role in the regulation of insulin sensitivity , and it is thought to be involved in the regulation of glucose uptake and storage in the pancreas.

Another potential mechanism by which GPRASP3 may be targeted by drugs is through its role in neurotransmission. GPRASP3 is involved in the regulation of neurotransmitter release from neurons, and it is thought to play a critical role in the regulation of neuronal excitability.

GPRASP3 has also been shown to be involved in the regulation of cell signaling pathways that are important in the development and progression of neurodegenerative diseases. For example, GPRASP3 has been shown to play a critical role in the regulation of the TGF-β pathway, which is involved in the development of neurodegenerative diseases.

In conclusion, GPRASP3 is a protein that is expressed in various tissues throughout the body and is involved in several critical biological processes, including cell signaling and neurotransmission. It is also a potential drug target for several diseases, including diabetes, obesity, and neurodegenerative diseases . Further research is needed to fully understand the role of GPRASP3 in these processes and to develop effective treatments.

Protein Name: G Protein-coupled Receptor Associated Sorting Protein Family Member 3

Functions: Survival and differentiation promoting protein that plays a role in the regulation of neurosynaptogenesis. Induces phosphatase PP2A activity which results in APP dephosphorylation and inhibits BACE1-mediated processing of APP

The "GPRASP3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GPRASP3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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