KAZALD1: A Potential Drug Target and Biomarker for Serine Peptidase Inhibition

Target Name: KAZALD1

NCBI ID: G81621

KAZALD1

Other Name(s): Kazal type serine peptidase inhibitor domain 1, transcript variant 1 | Kazal-type serine protease inhibitor domain-containing protein 1 | IGFBP-rP10 | bone- and odontoblast-expressed gene 1 | Kazal-type serine protease inhibitor domain 1 | Kazal-type serine protease inhibitor domain-containing protein 1 (isoform a) | Kazal type serine peptidase inhibitor domain 1 | FKSG28 | BONO1 | Novel kazal-type serine protease inhibitor domain and immunoglobulin domain containing protein | novel kazal-type serine protease inhibitor domain and immunoglobulin domain containing protein | FKSG40 | Bone- and odontoblast-expressed gene 1 | KAZALD1 variant 1 | IGFBP-related protein 10 | KAZD1_HUMAN

KAZALD1: A Potential Drug Target and Biomarker for Serine Peptidase Inhibition

Serine peptidase (SP) is a family of enzymes that play a crucial role in the regulation of intracellular signaling pathways. These enzymes are involved in the breakdown of serine-containing peptides, which are often involved in signaling pathways that regulate cell survival, growth, and differentiation. One of the serine peptidases, Kazaltype serine peptidase inhibitor domain 1 (KAZALD1), has been identified as a potential drug target and biomarker for several diseases.

KAZALD1 is a protein that contains a catalytic domain and a unique N-terminal region that is composed of a long oligomeric sequence and a shortspan helix. It is expressed in various cell types, including liver, pancreas, and heart, and is involved in the regulation of intracellular signaling pathways.

KAZALD1 functions as a serine peptidase inhibitor by inhibiting the activity of other serine peptidases. This inhibition results in the accumulation of free serine, which can then act as a signaling molecule to regulate various cellular processes.

One of the unique features of KAZALD1 is its ability to inhibit the activity of multiple serine peptidases, including the well-known serine proteases, 尾-secretin, and cathepsin D. This inhibition of these enzymes makes KAZALD1 a potential drug target for diseases that are characterized by the over-expression or dysfunction of these enzymes.

In addition to its role as a serine peptidase inhibitor, KAZALD1 has also been shown to play a role in cell signaling pathways. For example, KAZALD1 has been shown to be involved in the regulation of cell adhesion, migration, and invasion. Additionally, KAZALD1 has been shown to play a role in the regulation of cell apoptosis, which is a critical mechanism that helps cells eliminate themselves when they are no longer needed.

KAZALD1 has also been shown to be involved in the regulation of cellular signaling pathways that are involved in diseases such as cancer, neurodegenerative diseases, and autoimmune diseases. For example, KAZALD1 has been shown to play a role in the regulation of the T-cell receptor signaling pathway, which is involved in the regulation of immune cell function. Additionally, KAZALD1 has been shown to play a role in the regulation of the insulin signaling pathway, which is involved in the regulation of glucose metabolism and is often disrupted in diseases such as diabetes.

In conclusion, KAZALD1 is a protein that functions as a serine peptidase inhibitor and is involved in the regulation of various cellular processes that are important for the health and survival of cells. Its unique ability to inhibit the activity of multiple serine peptidases makes KAZALD1 a potential drug target for diseases that are characterized by the over-expression or dysfunction of these enzymes. Additionally, KAZALD1 has also been shown to play a role in the regulation of various cellular signaling pathways and is involved in the regulation of diseases such as cancer, neurodegenerative diseases, and autoimmune diseases. Further research is needed to fully understand the role of KAZALD1 in these diseases and to develop effective treatments.

Protein Name: Kazal Type Serine Peptidase Inhibitor Domain 1

Functions: Involved in the proliferation of osteoblasts during bone formation and bone regeneration. Promotes matrix assembly (By similarity)

The "KAZALD1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KAZALD1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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