KBTBD7: A Potential Drug Target for Stem Cell Biology and Chronic Inflammation

Target Name: KBTBD7

NCBI ID: G84078

KBTBD7

KBTBD7: A Potential Drug Target for Stem Cell Biology and Chronic Inflammation

KBTBD7 (KBTB7_HUMAN), also known as human KBTB7, is a protein that is expressed in various tissues of the human body. KBTBD7 has been identified as a potential drug target and has been shown to play a role in a variety of biological processes. In this article, we will explore the biology and potential drug targeting of KBTBD7 in more detail.

The KBTB7 gene is located on chromosome 12q14 and has been shown to encode a protein that is involved in the regulation of stem cell proliferation and differentiation. The protein encoded by the KBTB7 gene is composed of 258 amino acids and has a calculated molecular mass of 31.1 kDa. KBTB7 is highly conserved across various species, including humans, and has been shown to have similar structures in different organisms.

KBTB7 is involved in the regulation of stem cell proliferation and differentiation by promoting the formation of quiescent stem cells and limiting the production of differentiateing stem cells. This is done through the regulation of the cell cycle, specifically the G1/S transition, which is the stage at which a cell prepares for cell division. KBTB7 has been shown to promote the G1/S transition by activating the protein p21, which is involved in the regulation of the cell cycle.

In addition to its role in stem cell biology, KBTB7 is also involved in the regulation of cell adhesion and tissue organization. This is done through the regulation of the protein N-cadherin, which is involved in cell-cell adhesion and has been shown to play a role in the development and maintenance of tissues such as tissues and organs.

KBTB7 has also been shown to be involved in the regulation of inflammation. This is done through the regulation of the protein NF-kappa-B, which is involved in the regulation of inflammation and has been shown to play a role in the development of a variety of diseases, including cancer.

In addition to its role in biology, KBTB7 has also been identified as a potential drug target. Several studies have shown that KBTB7 is involved in a variety of cellular processes that are important for human health, including stem cell biology, cell adhesion, and inflammation. This makes KBTB7 an attractive target for drug development.

One of the potential mechanisms by which KBTB7 can be targeted with drugs is through its role in the regulation of the cell cycle. inhibitors of the protein p21, which is the target of the drug taxane, have been shown to inhibit the G1/S transition and prevent KBTB7-mediated cell proliferation. This suggests that drugs that inhibit the activity of p21 could be effective in targeting KBTB7 and potentially treating diseases associated with increased cell proliferation, such as cancer.

Another potential mechanism by which KBTB7 can be targeted with drugs is through its role in the regulation of cell adhesion. drugs that inhibit the activity of N-cadherin, which is the target of the drug P16, have been shown to prevent KBTB7-mediated cell adhesion and tissue organization. This suggests that drugs that inhibit the activity of N-cadherin could be effective in targeting KBTB7 and potentially treating diseases associated with disrupted tissue organization, such as cancer.

In addition to its potential role in drug targeting, KBTB7 has also been shown to be involved in the regulation of inflammation. drugs that inhibit the activity of NF-kappa-B, which is the target of the drug interleukin-1尾, have been shown to prevent KBTB7-mediated inflammation and potentially treat diseases associated with inflammation, such as cancer.

Overall, KBTB7 is a protein that is involved in a variety of biological processes and has been shown to play

Protein Name: Kelch Repeat And BTB Domain Containing 7

Functions: As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation (PubMed:25684205). By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation (PubMed:25684205). Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex (PubMed:25684205)

The "KBTBD7 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KBTBD7 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets