CHAF1B: A Potential Cancer Drug Target (G8208)

Target Name: CHAF1B

NCBI ID: G8208

CHAF1B

CHAF1B: A Potential Cancer Drug Target

Chromatin Assembly Factor I (CHAF1B) is a protein that plays a crucial role in the regulation of gene expression and DNA replication in various organisms, including humans. CHAF1B is a key component of the core chromatin domain, which is the region of the chromosome that contains the majority of genetic information.

CHAF1B functions as a cofactor for the protein chromatin-remodeling complex (CRC), which is responsible for the dynamic reassembly and disassembly of chromatin. The CRC is a complex of several proteins that work together to ensure the proper organization and regulation of chromatin.

CHAF1B helps to maintain the integrity of the CRC by providing a critical surface for the recruitment of CRC components. It does this by playing a key role in the regulation of the assembly and disassembly of the CRC.

One of the key functions of CHAF1B is its role in DNA replication. CHAF1B helps to ensure that the DNA replication machinery is properly organized and that the replication process is completed efficiently.

In addition to its role in DNA replication, CHAF1B is also involved in the regulation of gene expression. It does this by interacting with the protein transcription factor binding protein (TFBP), which is a protein that helps to ensure that the correct genetic information is transcribed into RNA.

CHAF1B is also involved in the regulation of cell cycle progression. It helps to ensure that the cell cycle is properly organized and that the cell divides correctly.

CHAF1B is a protein that has been identified as a potential drug target in the field of cancer. Studies have shown that high levels of CHAF1B are associated with poor prognosis in various types of cancer, including breast, ovarian, and colorectal cancers.

In addition to its involvement in cancer, CHAF1B is also involved in the regulation of normal cellular processes. It helps to ensure that the cell is properly organized and that it functions correctly.

CHAF1B is a protein that plays a crucial role in the regulation of gene expression and DNA replication in various organisms. Its functions include maintaining the integrity of the CRC, regulating DNA replication, and involved in the regulation of cell cycle progression.

As a result of its involvement in these processes, CHAF1B is a protein that has been identified as a potential drug target in the field of cancer. Studies have shown that high levels of CHAF1B are associated with poor prognosis in various types of cancer. Further research is needed to fully understand the role of CHAF1B in cancer and to develop effective treatments.

Protein Name: Chromatin Assembly Factor 1 Subunit B

Functions: Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer

The "CHAF1B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CHAF1B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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