LAGE3: A Non-Coding RNA Molecule Regulating Stem-Cell Niche (G8270)

Target Name: LAGE3

NCBI ID: G8270

LAGE3

LAGE3: A Non-Coding RNA Molecule Regulating Stem-Cell Niche

LAGE3 (long non-coding RNA 3) is a non-coding RNA molecule that has been identified as a potential drug target and biomarker. LAGE3 is a key regulator of the stem-cell niche and has been shown to play a role in the development and maintenance of cancer.

LAGE3 is a RNA molecule that is derived from the long non-coding RNA family. This family of RNA molecules are characterized by their ability to self-assemble into stable, double-stranded structures that can interact with a wide variety of proteins. LAGE3 is a member of the LAGE family and is responsible for regulating the stem-cell niche.

The stem-cell niche is a vital component of our bodies and is responsible for the development and maintenance of all tissues and organs. Stem cells are highly regenerative and have the ability to differentiate into any cell type in the body. This makes them an attractive target for drug developers because they can be used to treat a wide variety of diseases and conditions.

LAGE3 is shown to play a key role in the regulation of the stem-cell niche. It is a critical regulator of the stem-cell proliferation and maintenance of the stem-cell population. LAGE3 has been shown to interact with several key proteins that are involved in the stem-cell niche.

One of the proteins that LAGE3 interacts with is the transcription factor, SMAD. SMAD is a protein that is responsible for regulating gene expression and is a key player in the regulation of stem cells. LAGE3 has been shown to interact with SMAD and to play a role in the regulation of SMAD activity.

Another protein that LAGE3 interacts with is the RNA binding protein, CBP. CBP is a protein that is responsible for binding to RNA and is a key player in the regulation of gene expression. LAGE3 has been shown to interact with CBP and to play a role in the regulation of CBP activity.

In addition to its interactions with SMAD and CBP, LAGE3 has also been shown to interact with several other proteins that are involved in the stem-cell niche. These include the proteins, p53, and p21, which are involved in the regulation of cell cycle progression and apoptosis, respectively.

LAGE3 is also shown to play a role in the regulation of stem-cell differentiation. Stem cells have the ability to differentiate into any cell type in the body, and LAGE3 is thought to play a role in the regulation of this process.

One of the ways that LAGE3 is involved in the regulation of stem-cell differentiation is through its interactions with the transcription factor, Sox2. Sox2 is a key player in the regulation of stem-cell differentiation and is responsible for the production of stem cells with a specific type of gene expression. LAGE3 has been shown to interact with Sox2 and to play a role in the regulation of Sox2 activity.

Another way that LAGE3 is involved in the regulation of stem-cell differentiation is through its interactions with the protein, ZFP3. ZFP3 is a transcription factor that is involved in the regulation of stem-cell differentiation and is thought to play a role in the development of cancer. LAGE3 has been shown to interact with ZFP3 and to play a role in the regulation of ZFP3 activity.

In addition to its involvement in the regulation of stem-cell differentiation, LAGE3 is also shown to play a role in the regulation of stem-cell proliferation. Stem cells are highly regenerative and have the ability to divide and proliferate without limits, and LAGE3 is thought to play a role in this process.

One of the ways that LAGE3 is involved in the regulation of stem-cell proliferation is through its interactions with the protein, p21. P21 is a

Protein Name: L Antigen Family Member 3

Functions: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). LAGE3 functions as a dimerization module for the complex (PubMed:22912744, PubMed:27903914)

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