H4 Regulates Calbindin and Gene Expression in Cells (G8366)

Target Name: H4C2

NCBI ID: G8366

H4C2

Other Name(s): Histone H4 | H4C14 | H4/I | translation initiation factor IF-2-like | histone cluster 1 H4 family member b | H4C8 | H4_HUMAN | H4C12 | H4C11 | histone cluster 1, H4b | H4C9 | H4 histone family, member I | H4C5 | H4C6 | H4C16 | H4C15 | H4C3 | H4C1 | H4FI | HIST1H4B | H4C4 | histone 1, H4b | H4 clustered histone 2 | H4C13 | H4-16

H4 Regulates Calbindin and Gene Expression in Cells

Histone H4 (H4) is a protein that plays a critical role in the regulation of gene expression and cell signaling. It is a key component of histones, which are small non-coding RNAs that help to shape the three-dimensional structure of chromosomes. Histones are composed of four different proteins: histone alpha, histone beta, histone gamma, and histone delta. H4 is one of the proteins that makes up the histone complex.

H4 is a 20-kDa protein that consists of 192 amino acid residues. It has a characteristic alpha-helical structure, with a distinct N-terminal domain and a C-terminal domain that is involved in protein-protein interactions. The C-terminal domain is known as the \"calbindin domain\" and is responsible for the protein's unique ability to interact with the protein calbindin.

Calbindin is a protein that is often used as a biomarker for the diagnosis and prognosis of various diseases, including cancer. It is a 22-kDa protein that consists of 156 amino acid residues. It has a characteristic alpha-helical structure, with a distinct N-terminal domain and a C-terminal domain that is involved in protein-protein interactions.

H4 and calbindin have been shown to have a strong interaction, and H4 has been shown to play a critical role in the regulation of calbindin function. This is because H4 is able to interact with the calbindin protein in a way that allows it to alter the structure and function of the calbindin protein.

One of the key functions of H4 is its ability to regulate the level of calbindin in cells. This is done by H4's ability to interact with the calbindin protein and cause it to become aggregated or denatured, which in turn can lead to the formation of calbindin-containing structures in the cell. This can then be used as a biomarker for the presence of certain diseases or conditions.

Another function of H4 is its ability to regulate gene expression. This is done by H4's ability to interact with the RNA polymerase, which is the protein that transcribes DNA into RNA. By interacting with the RNA polymerase, H4 is able to regulate the access of transcription factors to the DNA and can thereby control the expression of specific genes.

H4 has also been shown to play a role in the regulation of cell signaling pathways. This is done by H4's ability to interact with the protein PDGF-2, which is a key regulator of cell signaling pathways. By interacting with PDGF-2, H4 is able to regulate the activity of the PDGF-2 protein and thereby control the signaling pathways that are involved in the development and progression of many diseases.

In conclusion, H4 is a protein that plays a critical role in the regulation of gene expression, cell signaling pathways, and the level of calbindin in cells. Its unique ability to interact with the calbindin protein makes it an attractive drug target and a potential biomarker for the diagnosis and prognosis of various diseases. Further research is needed to fully understand the mechanisms of H4's function in these processes and to develop effective treatments based on these insights.

Protein Name: H4 Clustered Histone 2

Functions: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

The "H4C2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about H4C2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets