TMEM222: A Potential Drug Target for Heart Disease, Diabetes and Cancer

Target Name: TMEM222

NCBI ID: G84065

TMEM222

TMEM222: A Potential Drug Target for Heart Disease, Diabetes and Cancer

TMEM222 (RP11-4K3__A.4) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. Its primary function is to regulate the structure and function of the blood vessels, which is essential for maintaining proper blood flow and oxygenation of tissues.

Recent studies have identified TMEM222 as a potential drug target or biomarker for various diseases, including heart disease, diabetes, and cancer. Its unique structure and function make it an attractive target for drug development due to its robustness and expression pattern.

TMEM222 is a member of the transmembrane protein family, which includes various proteins involved in tissue signaling and cell-cell communication. TMEM222 is characterized by a unique transmembrane domain that is composed of a long extracellular domain and a short intracellular domain. The transmembrane domain is responsible for the protein's unique structure and function.

The intracellular domain of TMEM222 is involved in the regulation of the actinin cytoskeleton, which is a protein that plays a critical role in the cytoskeleton's mechanical properties and functions. The actinin cytoskeleton is composed of two subunits, alpha and beta, which are held together by a disulfide bond. The intracellular domain of TMEM222 is involved in the regulation of the actinin cytoskeleton by affecting the stability and dynamics of the subunits.

TMEM222 is also involved in the regulation of the endothelium, which is the lining of the blood vessels. The endothelium plays a critical role in maintaining the blood vessels' integrity and barrier function. TMEM222 is characterized by the presence of a protein called pericyte, which is involved in the regulation of the endothelium. The pericyte protein helps to maintain the tightness of the endothelium and protect it from physical and chemical stress.

In addition to its role in the regulation of the blood vessels, TMEM222 is also involved in the regulation of various signaling pathways that are important for maintaining cellular homeostasis. One of these signaling pathways is the TGF-beta pathway, which is involved in the regulation of cell growth, differentiation, and survival. TMEM222 is known to play a role in the regulation of TGF-beta signaling by affecting the activity of the transcription factor Smad2.

In conclusion, TMEM222 is a unique protein that is involved in the regulation of various physiological processes in the body. Its structure and function make it an attractive target for drug development due to its robustness and expression pattern. Further studies are needed to fully understand the role of TMEM222 in the regulation of the blood vessels and other physiological processes.

Protein Name: Transmembrane Protein 222

The "TMEM222 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMEM222 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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